日本繁殖生物学会賞・優秀発表賞 MAPキナーゼおよびプロテインチロシンホスファターゼの顆粒膜細胞における役割
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概要
- 論文の詳細を見る
A number of endocrine and paracrine factors regulate the follicular growth and atresia, which are closely associated with granulosa cell survival and apoptosis. However, the molecular mechanisms underlying the intracellular events induced by these factors are poorly understood. Here, we describe the correlation of mitogen-activated protein kinase (MAPK) activities with granulosa cell survival and apoptosis, and the cellular functions of protein tyrosine phosphatases (PTPs) in these cells based on our recent data. MAPKs play key roles in various cellular responses because numerous extracellular stimuli are integrated into MAPKs. The protein phospho-Tyr level regulated by protein tyrosine kinases (PTKs) and PTPs is a major control mechanism for processes as diverse as cell survival, proliferation, differentiation, and metabolism. Although PTKs are critically involved in granulosa cell survival and proliferation, there are no reports indicating the roles of PTPs in the ovary except for ours. Information about MAPKs and PTPs in these cells will provide a basis for the understanding of the molecular mechanisms controlling the fate of follicles.
著者
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Shimizu Hidehisa
Gene Research Center, University of Tsukuba
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Miyazaki Hitoshi
Gene Research Center, University of Tsukuba
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MIYANO Takashi
Graduate School of Agricultural Science, Kobe University
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田村 真理子
筑波大学遺伝子実験センター
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清水 英寿
筑波大学遺伝子実験センター
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Miyazaki Hitoshi
Gene Experiment Center Institute Of Applied Biochemistry
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Shimizu Hidehisa
Gene Research Center University Of Tsukuba
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TAMURA Mariko
Gene Research Center, University of Tsukuba
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NAKAGAWA Yosimi
Gene Research Center, University of Tsukuba
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YAMADA Noriaki
Gene Research Center, University of Tsukuba
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Miyano Takashi
Graduate School Of Agricultural Sci. Kobe Univ.
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田村 真理子
Gene Research Center, University of Tsukuba
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中川 嘉
Gene Research Center, University of Tsukuba
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清水 英寿
Gene Research Center, University of Tsukuba
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- MAPキナーゼおよびプロテインチロシンホスファターゼの顆粒膜細胞における役割
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