Interactions between the Oocyte and Surrounding Somatic Cells in Follicular Development : Lessons from In Vitro Culture

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概要

• 論文の詳細を見る

• Mammalian oogenesis occurs concomitantly with folliculogenesis in a coordinated manner in the ovaries. In vitro growth (IVG) culture systems of the oocytes have been developed as a new technology for utilizing incompetent oocytes in the ovary as a source of mature oocytes as well as for studying oogenesis, folliculogenesis, and oocyte-somatic cell interactions. The results of IVG experiments have suggested that direct association of oocytes and surrounding granulosa cells supports oocyte viability and growth through the gap junctions, which are efficient conduits for low molecular weight substances. It has been revealed that granulosa cells metabolize some molecules which are in turn transported into the oocytes. IVG systems have also provided evidence that FSH promotes the development of follicles at secondary or later stages by its stimulation of proliferation and differentiation of granulosa cells, and perhaps by its anti-apoptotic effects. In addition, interactions between granulosa cell-derived KIT ligands and oocyte KIT receptors have been suggested as initiating oocyte growth and follicular development. Furthermore, recent findings suggest there are growth factors derived from oocytes such as GDF-9 and BMP-15. With such factors, oocytes participate in follicular development by regulating the differentiation of surrounding somatic cells. These bidirectional communications between oocytes and somatic cells are important for oocyte growth and follicular development. IVG systems should provide further information regarding oogenesis and folliculogenesis in the ovary.

• 日本繁殖生物学会の論文
• 2003-08-01

著者

• MIYANO Takashi

  Laboratory of Reproductive Biology and Biotechnology, Faculty of Agriculture, Kobe University

• Hirao Yuji

  Department Of Animal Production And Grasslands Farming National Agricultural Research Center For Toh

• Miyano Takashi

  Laboratory Of Reproductive Biology And Biotechnology Faculty Of Agriculture Kobe University

• Miyano Takashi

  Laboratory Of Reproductive Biology & Biotechnology Faculty Of Agriculture Kobe University

• SENBON Shoichiro

  Graduate School of Science and Technology, Faculty of Agriculture, Kobe University

• Miyano T

  Laboratory Of Reproductive Biology And Biotechnology Faculty Of Agriculture Kobe University

• Senbon Shoichiro

  Graduate School Of Science And Technology Kobe University

• Miyano Takashi

  Laboratory Of Animal Breeding And Reproduction Faculty Of Agriculture Kobe University

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