Two Cases of Mediastinal Gray Zone Lymphoma
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概要
- 論文の詳細を見る
Mediastinal gray zone lymphoma (MGZL) represents a range of tumors possessing characteristics of both nodular sclerosis classical Hodgkin lymphoma (NSHL) and mediastinal large B-cell lymphoma (MLBCL). Here we report two patients with MGZL. Patient 1 was a 30-year-old woman and patient 2 was a 22-year-old man. Both patients had a mediastinal mass, were initially diagnosed with NSHL and exhibited resistance to first-line chemotherapy. Re-biopsy of the relapsed tumors or the residual lesion was performed and based on the findings the tumors were diagnosed as MGZL. In patient 1, the morphological features of the tumor resembled those of NSHL, but the immunophenotypic features indicated MLBCL. In patient 2, the tumor was a composite lymphoma with both NSHL and MLBCL components. Both the patients received high-dose chemotherapy followed by autologous peripheral-blood stem-cell transplantation. Although there is an overlap in the biological and morphological features between NSHL and MLBCL, the therapeutic approaches to NSHL and MLBCL are quite different. The development of effective therapies for MGZL is therefore extremely critical.
- 日本リンパ網内系学会の論文
- 2010-11-01
著者
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Yamaguchi Yuko
Division Of Oncology And Hematology Department Of Internal Medicine Jikei University School Of Medic
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USUI Noriko
Division of Oncology and Hematology, Department of Internal Medicine, Jikei University School of Med
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ASAI Osamu
Division of Oncology and Hematology, Department of Internal Medicine, Jikei University School of Med
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DOBASHI Nobuaki
Division of Oncology and Hematology, Department of Internal Medicine, Jikei University School of Med
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YANO Shingo
Division of Oncology and Hematology, Department of Internal Medicine, Jikei University School of Med
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OSAWA Hiroshi
Division of Oncology and Hematology, Department of Internal Medicine, Jikei University School of Med
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TAKEI Yutaka
Division of Oncology and Hematology, Department of Internal Medicine, Jikei University School of Med
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TAKAHARA Shinobu
Division of Oncology and Hematology, Department of Internal Medicine, Jikei University School of Med
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OGASAWARA Yoji
Division of Oncology and Hematology, Department of Internal Medicine, Jikei University School of Med
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MINAMI Jiro
Division of Oncology and Hematology, Department of Internal Medicine, Jikei University School of Med
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AIBA Keisuke
Division of Oncology and Hematology, Department of Internal Medicine, Jikei University School of Med
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YAHAGI Yuichi
Division of Hematology and Oncology, Department of Internal Medicine, Jikei University School of Med
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Usubuchi Noriko
国立がんセンター中央病院
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Usubuchi Noriko
Hematology And Oncology Division National Cancer Center Hospital East
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Uike Naokuni
Department Of Hematology National Kyushu Cancer Center
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Uike Naokuni
Department Of Hematology National Kyushu Cancer Center Hospital
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Uike N
National Kyusyu Cancer Center
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Uoshima Nobuhiko
京都府立医科大学 血液・腫瘍内科学
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Uoshima Nobuhiko
Matsushita Memorial Hospital Moriguchi Jpn
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Uoshima Nobuhiko
1st Department Of Internal Medicine Kyoto Prefectureal University Of Medicine
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Usui Noriko
東京慈恵会医科大学附属病院 中央検査部
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Usui N
Division Of Hematology And Oncology Department Of Medicine Jikei University
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Usui Noriko
Jikei University Hospital
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DOBASHI Nobuaki
Jikei University Hospital
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Dobashi Nobuaki
東京慈恵会医科大学 内科学(血液・腫瘍)
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Dobashi Nobuaki
Division Of Hematology And Oncology Department Of Internal Medicine Jikei University School Of Medic
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Usui N
Jikei University Hospital
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Minami Jiro
東京慈恵会医科大学 内科学(血液・腫瘍)
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Minami Jiro
Division Of Oncology And Hematology Department Of Internal Medicine Jikei University School Of Medic
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Aiba Keisuke
Division Of Clinical Chemotherapy Cancer Chemotherapy Center Japanese Foundation For Cancer Research
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Aiba Keisuke
Division Of Oncology And Hematology Department Of Internal Medicine Jikei University School Of Medic
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Aiba Keisuke
Department Of Medical Oncology Cancer Institute Hospital
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Uike Naokuni
Department Of Hemato-oncology Kyushu Cancer Center
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Asai Osamu
Department Of Clinical Oncology And Hematology School Of Medicine The Jikei University
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Takei Yutaka
Division Of Oncology And Hematology Department Of Internal Medicine Jikei University School Of Medic
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Yahagi Yuichi
Division Of Hematology And Oncology Department Of Internal Medicine Jikei University School Of Medic
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Otsubo Hiroko
Division Of Hematology And Oncology Department Of Medicine Jikei University
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Otsubo Hiroko
Division Of Oncology And Hematology Department Of Internal Medicine Jikei University School Of Medic
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Ogasawara Yoji
Division Of Oncology And Hematology Department Of Internal Medicine Jikei University School Of Medic
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NIKAIDO TAKASHI
Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University
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Nikaido Takashi
Department Of Diagnostic Pathology Chiba University Hospital
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Osawa Hiroshi
Division Of Oncology And Hematology Department Of Internal Medicine Jikei University School Of Medic
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MORIKAWA Noriyuki
Division of Research & Development, GUNZE Ltd.
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TAKADA Satoru
Leukemia Research Center, Saiseikai Maebashi Hospital
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Usui Noriko
Jikei Univ. Hospital Tokyo Jpn
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Usui Noriko
The "lung Injury By Bortezomib" Joint Committee Of The Japanese Society Of Hematology And
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Asai Osamu
Division Of Oncology And Hematology Department Of Internal Medicine Jikei University School Of Medic
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Dobashi Nobuaki
Jikei Univ. Hospital Tokyo Jpn
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Takahara Shinobu
Division Of Oncology And Hematology Department Of Internal Medicine Jikei University School Of Medic
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Yano Shingo
Division Of Oncology And Hematology Department Of Internal Medicine Jikei University School Of Medic
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Usui Noriko
Division Of Oncology & Hematology Department Of Internal Medicine The Jikei University School Of
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Usui Noriko
Division Of Hematology And Oncology Department Of Internal Medicine Jikei University School Of Medic
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Minami Jiro
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School
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KOBAYASHI Tatsunosuke
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University Scho
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Takahara Shinobu
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School
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Osawa Hiroshi
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School
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Ogasawara Yoji
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School
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Yano Shingo
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School
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Asai Osamu
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School
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Yamaguchi Yuko
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School
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Takei Yutaka
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School
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Nikaido Takashi
Department Of Pathology Jikei University School Of Medicine
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Morikawa Noriyuki
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School
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Aiba Keisuke
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School
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Sasaki T
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School
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Osawa Hiroshi
Division Of Cardiovascular Surgery Shimada General Hospital
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Kobayashi Tatsunosuke
Division Of Clinical Oncology And Hematology Department Of Internal Medicine Jikei University School Of Medicine
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DOBASHI Nobuaki
Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine
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