Estimation of Cell Membrane Permeability and Intracellular Diffusion Coefficient of Human Gray Matter
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概要
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The signal intensity of diffusion-weighted imaging (DWI) is sensitive to the intra- and extracellular diffusion coefficient of water and cell membrane permeability. We applied a method we proposed in previous papers to estimate noninvasively the membrane permeability and intracellular diffusion coefficient of normal human brain (gray matter) in 3 normal volunteers. We theoretically compared predicted signals and experiment results using a 1.5-tesla magnetic resonance (MR) imaging system. We acquired images using an echo planar imaging (EPI) sequence, applying motion-probing gradient (MPG) pulses in 3 directions. We periodically performed numerical simulations for various combinations of membrane permeability and intracellular diffusion coefficients using the finite-difference method. By minimizing the difference between signals obtained experimentally and those from numerical simulation, we could estimate membrane permeability (76±9 mm2/s μm) and intracellular diffusion coefficient (1.0±0.0 mm2/s) for the human brain. The estimated membrane permeability was the criterion value for diagnosing disease in gray matter.
- 日本磁気共鳴医学会の論文
- 2009-03-01
著者
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Ohtomo Kuni
Department Of Radiology Faculty Of Medicine University Of Tokyo
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Ueno Shoogo
Graduate School Of Engineering Kyushu University
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Ohtomo Kuni
Department Of Radiology University Of Tokyo Hospital
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Ohtomo Kuni
Department Of Radiology Faculty Of Medicin University Of Tokyo
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IMAE Toshikazu
Department of Radiology, University of Tokyo Hospital
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SHINOHARA Hiroyuki
Graduate School of Human Health Science, Tokyo Metropolitan University
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SEKINO Masaki
Graduate School of Frontier Sciences, University of Tokyo
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OHSAKI Hiroyuki
Graduate School of Frontier Sciences, University of Tokyo
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MIMA Kazuo
Department of Radiology, University of Tokyo Hospital
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Shinohara Hiroyuki
Graduate School Of Human Health Science Tokyo Metropolitan University
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Mima Kazuo
Department Of Radiology University Of Tokyo Hospital
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Sekino Masaki
Graduate School Of Frontier Sciences University Of Tokyo
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Imae Toshikazu
Department Of Radiology University Of Tokyo Hospital
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Ohsaki Hiroyuki
Graduate School Of Frontier Sciences University Of Tokyo
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Ohsaki Hiroyuki
Graduate School Of Engineering Science Osaka University
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OHTOMO Kuni
Department of Radiology, University of Tokyo Hospital
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