Green Tea Catechins Improve Human Forearm Endothelial Dysfunction and Have Antiatherosclerotic Effects in Smokers
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概要
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Background: Because green tea reduces cardiovascular and cerebrovascular risk, the purpose of this study aimed to elucidate the effect of green tea catechins (GTC) on endothelial dysfunction in smokers. Methods and Results: The 30 healthy male smokers were divided into 3 groups and given green tea beverages containing 0 mg (control group), 80 mg (medium-dose group) or 580 mg (high-dose group) of GTC daily for 2 weeks. Endothelial-dependent and- independent vasodilatation was investigated by measuring the forearm blood flow (FBF) responses to acetylcholine and sodium nitroprusside using venous occlusion strain-gauge plethysmography. The FBF response to acetylcholine significantly increased at 2 h and 1 and 2 weeks after GTC intake in the high-dose group, but no increase was observed in the other groups. FBF responses to sodium nitroprusside did not alter in any group at any time point. A significant increase in plasma nitric oxide and a decrease in asymmetrical dimethylarginine, malondealdehyde and 4-hydroxynonenal, C-reactive protein, monocyte chemotactic protein-1, and soluble CD40 ligand levels were detected after chronic consumption of high-dose GTC. Conclusions: GTC have antiatherosclerotic effects on dysfunctional vessels in smokers through increasing the level of nitric oxide and reducing oxidative stress.
- 2010-02-25
著者
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OYAMA Jun-ichi
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
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MAEDA Toyoki
Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Bepp
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KOUZUMA Kazuya
Kao Corporation
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OCHIAI Ryuji
Kao Corporation
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TOKIMITSU Ichiro
Kao Corporation
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HIGUCHI Yoshihiro
Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Bepp
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SUGANO Masahiro
Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Bepp
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MAKINO Naoki
Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Bepp
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Makino Naoki
Medical Institute of Bioregulation. Kyushu University
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Makino Naoki
Department Of Cardiovascular Respiratory And Geriatric Medicine Kyushu University Hospital At Beppu
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Makino Naoki
Division Of Molecular And Clinical Gerontology Medical Inst. Of Bioregulation Kyushu Univ.
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Makino Naoki
Department Of Bioclimatology And Medicine Medical Institute Of Bioregulation Kyushu University
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Maeda Toyoki
Department Of Cardiovascular Respiratory And Geriatric Medicine Kyushu University Hospital At Beppu
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Oyama Jun-ichi
Department Of Cardiovascular Respiratory And Geriatric Medicine Kyushu University Hospital At Beppu
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Oyama Jun-ichi
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Sciences
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Makino Naoki
Division Of Molecular And Clinical Gerontology Department Of Molecular And Cellular Biology Medical
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Higuchi Yoshihiro
Department Of Cardiovascular Respiratory And Geriatric Medicine Kyushu University Hospital At Beppu
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Higuchi Yoshihiro
Department Of Applied Quantum Physics Faculty Engineering Graduate School Of Kyusyu University
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Sugano Masahiro
Division Of Molecular And Clinical Gerontology Department Of Molecular And Cellular Biology Medical
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Sugano Masahiro
Department Of Cardiovascular Respiratory And Geriatric Medicine Kyushu University Hospital At Beppu
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Makino Naoki
Departent Of Bioclimatology And Medicine Medical Institute Of Bioregulation Kyushu University
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Sugano Masahiro
Division Of Molecular And Clinical Gerontology Medical Inst. Of Bioregulation Kyushu Univ.
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Sugano Masahiro
Department Of Molecular And Cellular Biology Division Of Molecular And Clinical Gerontology Medical
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Makino Naoki
Department Of Molecular And Cellular Biology Division Of Molecular And Clinical Gerontology Medical
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Oyama Junichi
Department Of Molecular And Cellular Biology Division Of Molecular And Clinical Gerontology Medical
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Sugano Masahiro
Department Of Bioclimatology And Medicine Medical Institute Of Bioregulation Kyushu University
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