Diagonal Earlobe Crease are Associated With Shorter Telomere in Male Japanese Patients With Metabolic Syndrome : A Pilot Study(Epidemiology)

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概要

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• Background Diagonal earlobe crease (ELC) have been proposed as a marker of generalized atherosclerosis, so in the present study it was investigated whether individuals with ELC have a shortened telomere, which correlates with an accelerated cell turnover and premature aging, leading to atherosclerosis. Methods and Results The mean terminal restriction fragment (TRF) was determined by Southern blot hybridization in the peripheral blood cells of 34 male Japanese patients with metabolic syndrome (MetS) who were under 70 years of age with (n=17) and without (n=17) bilateral ELC, and assessed the relationship of ELC to atherosclerotic cardiovascular disease (AVD). The results showed that the TRF was shorter in the MetS patients with ELC in comparison to age- and risk-factor-matched MetS patients without ELC (7.6±1.1kbp vs 8.6±1.2kbp; P<0.05). ELC were present in 13 patients in the AVD group (n=18), but only 4 patients in the non-AVD group (n=16) had ELC (72.2% and 25% respectively; P<0.05). Conclusions These findings suggest that ELC is a useful dermatological indicator of an accelerated aging process, as suggested by excessive telomere loss, and might be a useful indirect marker of high-risk patients.

• 2009-01-20

著者

• Sugano Masahiro

  Medical Institute of Bioregulation. Kyushu University

• Makino Naoki

  Medical Institute of Bioregulation. Kyushu University

• Makino Naoki

  Department Of Cardiovascular Respiratory And Geriatric Medicine Kyushu University Hospital At Beppu

• Makino Naoki

  Division Of Molecular And Clinical Gerontology Medical Institute Of Bioregulation Kyushu University

• Makino Naoki

  Division Of Molecular And Clinical Gerontology Medical Inst. Of Bioregulation Kyushu Univ.

• Makino Naoki

  Department Of Bioclimatology And Medicine Medical Institute Of Bioregulation Kyushu University

• Maeda Toyoki

  Department Of Cardiovascular Respiratory And Geriatric Medicine Kyushu University Hospital At Beppu

• Oyama Jun-ichi

  Department Of Cardiovascular Respiratory And Geriatric Medicine Kyushu University Hospital At Beppu

• Makino Naoki

  Division Of Molecular And Clinical Gerontology Department Of Molecular And Cellular Biology Medical

• Oyama Junichi

  Division of Molecular and Clinical Gerontology, Medical Institute of Bioregulation, Kyushu Universit

• Oyama Junichi

  Division Of Molecular And Clinical Gerontology Medical Institute Of Bioregulation Kyushu University

• Higuchi Yoshihiro

  Department Of Cardiovascular Respiratory And Geriatric Medicine Kyushu University Hospital At Beppu

• Higuchi Yoshihiro

  Division Of Molecular And Clinical Gerontology Medical Institute Of Bioregulation Kyushu University

• Sugano Masahiro

  Division Of Molecular And Clinical Gerontology Department Of Molecular And Cellular Biology Medical

• Sugano Masahiro

  Department Of Cardiovascular Respiratory And Geriatric Medicine Kyushu University Hospital At Beppu

• Guan Jing-zhi

  Division Of Molecular And Clinical Gerontology Department Of Molecular And Cellular Biology Medical

• Sugano Masahiro

  Division Of Molecular And Clinical Gerontology Medical Inst. Of Bioregulation Kyushu Univ.

• Maeda Toyoki

  Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medica

• Sugano Masahiro

  Department Of Molecular And Cellular Biology Division Of Molecular And Clinical Gerontology Medical

• Makino Naoki

  Department Of Molecular And Cellular Biology Division Of Molecular And Clinical Gerontology Medical

• Sugano Masahiro

  Department Of Cardiovascular Respiratory And Geriatric Medicine Kyushu University Hospital At Beppu

• Oyama Junichi

  Department Of Molecular And Cellular Biology Division Of Molecular And Clinical Gerontology Medical

• Makino Naoki

  Division Of Molecular And Clinical Gerontology Department Of Molecular And Cellular Biology Medical

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