電気化学的手法によるチオグリコシドのグリコシルトリフラートへの変換

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概要

• 論文の詳細を見る

• 重要なグリコシル化反応中間体であるグリコシルトリフラートがチオグリコシドの低温電解酸化によって発生・蓄積可能であることを見出した。グルコース，ガラクース，マンノース由来のチオグリコシドをテトラブチルアンモニウムトリフラート（Bu4NOTf）存在下で低温電解酸化した陽極溶液の NMR 測定を行うことにより，グリコシルトリフラートの生成が確認出来た。また，電気化学的に発生させたグリコシルトリフラートの熱的安定性や糖受容体との反応も検討した。

• FCCA(Forum: Carbohydrates Coming of Age)の論文
• 2008-09-02

著者

• Nokami Toshiki

  Department Of Synthetic And Biological Chemistry Graduate School Of Engineering Kyoto University

• YOSHIDA Jun-ichi

  Department of Synthetic Chemistry & Biologycal Chemistry, Faculty of Engineering, Kyoto University

• SHIBUYA Akito

  Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University

• Shibuya Akito

  Department Of Synthetic And Biological Chemistry Graduate School Of Engineering Kyoto University

• Yoshida Jun-ichi

  Department Of Biological Science Faculty Of Science Kumamoto University

• Yoshida Junichi

  Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine

• Yoshida Junichi

  Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University

• Nokami Toshiki

  Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University

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