Increased Induction of Inducible Nitric Oxide Synthase Expression in Aortae of Type 2 Diabetes Rats
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概要
- 論文の詳細を見る
The aim of this study was to determine whether the pathway of inducible NO synthase (iNOS) in blood vessels is changed by type 2 diabetes. Lipopolysaccharide (LPS)-induced nitric oxide (NO) production and expression of iNOS and effects of LPS on phenylephrine-induced contractile force were compared in aortae isolated from Goto-Kakizaki (G-K) diabetes rats and aortae isolated from control Wistar rats. Both LPS-stimulated nitrite generation and iNOS expression levels were significantly higher in aortae from G-K rats than in those from control rats. Phenylephrine-induced contractile force in the presence of LPS was significantly lower in aortae from G-K rats than in those from control rats, while contractile force in the absence of LPS was comparable in the diabetic and control groups. On the other hand, incubation of aortae in high glucose-containing medium did not affect the LPS-stimulated nitrite accumulation and iNOS expression and the phenylephrine-induced contractile force, regardless of the presence of LPS. These results suggest that LPS-induced NO production through the iNOS pathway is increased and subsequent attenuation of contractile force by excess NO is enhanced in arteries of rats with type 2 diabetes.
- 社団法人 日本薬理学会の論文
- 2008-06-20
著者
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Takahashi Yuji
Department of Neurology, Graduate School of Medicine, University of Tokyo
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WAKABAYASHI Ichiro
Department of Hygiene & Preventive Medicine
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NAKANO Tomoyuki
Department of General Thoracic Surgery and Pulmonary Medicine, Jichi Medical University and Saitama
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Wakabayashi Ichiro
Department Of Environmental And Preventive Medicine Hyogo College Of Medicine
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Takahashi Yuji
Department Of Internal Medicine Division Of Cardiology And Memorial Heart Center Iwate Medical Unive
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Nakano Tomoyuki
Dep. Of Environmental And Preventive Medicine Hyogo Coll. Of Medicine Jpn
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Nakano Tomoyuki
Department Of Anatomy And Cell Biology Yamagata University School Of Medicine
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Takahashi Yuji
Department Of Environmental And Preventive Medicine Hyogo College Of Medicine
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Takahashi Yuji
Department Of Dermatology Course Of Integrated Medicine Graduate School Of Medicine Osaka University
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