Acidosis Inhibits Gallbladder Contraction Mediated by Protein Kinase C Activation
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概要
- 論文の詳細を見る
The effects of extracellular acidosis on gallbladder contraction were investigated using gallbladder strips isolated from guinea pigs. In an acidic medium (pH 6.9), gallbladder contraction induced by histamine and prostaglandin E2 was significantly lower than that in a normal medium (pH 7.4). Acidosis affected neither gallbladder contraction induced by histamine in the absence of extracellular Ca2+ nor that induced by KCl. Acidosis significantly inhibited Ca2+-induced contraction in the presence of sodium fluoride and phorbol 12,13-dibutyrate but not that in the presence of KCl. Staurosporine (30 nM) significantly inhibited gallbladder contraction induced by histamine and prostaglandin E2, but not that by KCl. Histamine-induced contraction in the presence of staurosporine was not affected by acidosis. Acidosis significantly inhibited Ca2+-induced contraction in the presence of histamine but not that in the presence of both histamine and staurosporine. These results suggest that extracellular acidosis selectively inhibits gallbladder contraction mediated by protein kinase C activation.
- 社団法人 日本薬理学会の論文
- 2001-10-01
著者
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Iwata Nobuo
2nd Department Of Internal Medicine Hyogo College Of Medicine
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Wakabayashi Ichiro
Department Of Environmental And Preventive Medicine Hyogo College Of Medicine
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Masui Hidehisa
Department Of Public Health Hyogo College Of Medicine
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Masui Hidehisa
Department Of Hygiene Hyogo College Of Medicine
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KATAOKA Yasuro
Department of Hygiene and preventive Medicine, School of Medicine, Yamagata University, 2nd Departme
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Kataoka Yasuro
Department Of Hygiene And Preventive Medicine School Of Medicine Yamagata University 2nd Department
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