Hemin Modulates Cytokine Expressions in Macrophage-Derived Foam Cells via Heme Oxygenase-1 Induction
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概要
- 論文の詳細を見る
Lipid-laden foam cells were considered to be targets for therapeutic intervention in atherosclerosis. Several studies proposed new approaches to alter both lipid accumulation and inflammatory responses in macrophages. Finding anti-inflammatory signals during foam cell formation would provide new valid targets for anti-atherosclerotic treatment. The aim of the present study was to see whether oxidized low-density lipoprotein (ox-LDL) can active heme oxygenase (HO)-1 expression level in a human monocyte line, U937 cells, associated with the increase of cytokine secretion. We used hemin (HO-1 activator) and zinc protoporphyrin IX (ZnPP IX, HO-1 inhibitor) to determine the effect of HO-1 on the regulation of cytokine expressions. The results showed that hemin can significantly decrease pro-inflammatory cytokines interleukin (IL)-1β and tumor necrosis factor (TNF)-α levels, while enhancing IL-10 production in a dose-dependent manner in U937 foam cells. ZnPP IX did not significantly affect cytokine levels in foam cells. Our present results suggested that HO-1 is an important anti-inflammatory therapeutic target through inhibiting pro-inflammatory cytokines and enhancing anti-inflammatory cytokines for the management of atherogenesis.
- 社団法人 日本薬理学会の論文
- 2007-03-20
著者
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Yang Peng-yuan
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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RUI Yao-Cheng
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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MA Jian-Li
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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LU Ling
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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KANG Hui
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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ZHANG Jing
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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Rui Yao-cheng
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Zhang Jing
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Ma Jian-li
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Kang Hui
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Lu Ling
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Zhang Jing
Department Of Information And Communication Engineering Xi'an Jiaotong University
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Yang Peng-yuan
Department Of Chemistry & Institutes Of Biomedical Sciences Fudan University
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Zhang Jing
Department Of Anatomy Histology & Embryology School Of Basic Medical Sciences Peking University
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LU Ling
Department of Obstetrics and Gynecology, Mianyang Central Hospital
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