Reduction of Atherosclerosis in Cholesterol-Fed Rabbits and Decrease of Expressions of Intracellular Adhesion Molecule-1 and Vascular Endothelial Growth Factor in Foam Cells by a Water-Soluble Fraction of Polygonum multiflorum
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概要
- 論文の詳細を見る
Polygonum multiflorum stilbeneglycoside (PMS) is a water-soluble fraction of Polygonum multiflorum Thunb., one of the most famous tonic traditional Chinese medicines, that has protective effects on the cardiovascular system. The purpose of the present study is to elucidate the effects of PMS on macrophage-derived foam cell functions and the reduction of severity of atherosclerosis in hypercholesterolemic New Zealand White (NZW) rabbits. NZW rabbits were fed for 12 weeks with a normal diet, a high cholesterol diet, or a high cholesterol diet associated with irrigation with different doses of PMS (25, 50, or 100 mg/kg). Treatment of NZW rabbits fed with high cholesterol diet with 100 mg/kg PMS attenuated the increase in plasma cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and plasma triglyceride. Treatment with 50 and 100 mg/kg PMS caused 43% and 60% decrease in atherosclerotic lesioned area ratio to total surface area, respectively. In U937 foam cells, PMS could decrease the high expression of intercellular adhesion molecule (ICAM)-1 protein and the vascular endothelial growth factor (VEGF) protein levels in the medium induced by oxidized lipoprotein when analyzed by flow cytometry. The results proved that PMS is a powerful agent against atherosclerosis and that PMS action could possibly be through the inhibition of the expression of ICAM-1 and VEGF in foam cells.
- 社団法人 日本薬理学会の論文
- 2005-11-20
著者
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Li Tie-jun
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Yang Peng-yuan
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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RUI Yao-Cheng
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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YANG Peng-Yuan
School of Pharmacy, Second Military Medical University
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ALMOFTI Mohamad
School of Pharmacy, Second Military Medical University
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LU Ling
School of Pharmacy, Second Military Medical University
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KANG Hui
School of Pharmacy, Second Military Medical University
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ZHANG Jing
School of Pharmacy, Second Military Medical University
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LI Tie-Jun
School of Pharmacy, Second Military Medical University
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RUI Yao-Cheng
School of Pharmacy, Second Military Medical University
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SUN Lian-Na
School of Pharmacy, Second Military Medical University
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CHEN Wan-Sheng
School of Pharmacy, Second Military Medical University
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LU Ling
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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KANG Hui
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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ZHANG Jing
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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Rui Yao-cheng
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Chen Wan-sheng
Department Of Pharmacy Changzheng Hospital
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Zhang Jing
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Sun Lian-na
School Of Pharmacy Second Military Medical University
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Kang Hui
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Lu Ling
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Almofti Mohamad
School Of Pharmacy Second Military Medical University
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Zhang Jing
School Of Environmental And Biological Science And Technology Dalian University Of Technology
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