Protective Effects of Guizhi-Fuling-Capsules on Rat Brain Ischemia/Reperfusion Injury

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概要

• 論文の詳細を見る

• Previous studies revealed that Guizhi-Fuling-Capsules (GZFLC), a traditional Chinese medical (Kampo) formulation composed of five kinds of medicinal plants, Cinnamomum cassia B<sc>LUME</sc> (Cinnamomi Cortex), Paeonia lactiflora P<sc>ALL</sc>. (Peonies Radix), Paeonia suffruticosa A<sc>NDREWS</sc> (Moutan Cortex), Prunus persica B<sc>ATSCH</sc> (Persicae Semen), and Poria cocos W<sc>OLF</sc> (Hoelen), exerts a protective effect against vascular injury and has a protective effect against glutamate- or nitro oxide-mediated neuronal damage. In the present study, the effect of GZFLC in a rat in vivo model of focal cerebral ischemia and reperfusion was investigated. Administration of GZFLC (0.3 and 0.9 g/kg, p.o.) after focal cerebral ischemia significantly decreased brain infarction and water contents in rats subjected to 2-h ischemia followed by 24-h reperfusion from 31.72 ± 2.49%, 84.76 ± 1.63% in the model group to 17.31 ± 3.66%, 82.51 ± 1.36% and 8.30 ± 3.73%, 81.35 ± 1.73%, respectively. Furthermore, analysis of inflammatory cytokines in ischemic brain showed that GZFLC treatment significantly down-regulated expressions of pro-inflammatory cytokines including interleukin (IL)-1β and tissue necrosis factor-α and markedly up-regulated expressions of anti-inflammatory cytokines IL-10 and IL-10R both in mRNA and protein levels. The serum levels of these inflammatory cytokines were also regulated the same way. These results suggested that GZFLC may be beneficial for the treatment of brain ischemia-reperfusion injury partly due to its anti-inflammatory properties.

• 社団法人 日本薬理学会の論文
• 2007-09-20

著者

• Li Tie-Jun

  Department of Oral Pathology Kagoshima University Dental School

• Li Tie-jun

  Department Of Pharmacology School Of Pharmacy Second Military Medical University

• Yang Peng-yuan

  Department Of Pharmacology School Of Pharmacy Second Military Medical University

• QIU Yan

  Department of Pharmacology, School of Pharmacy, Second Military Medical University

• MAO Jun-Qin

  Department of Pharmacy, 85 Hospital

• RUI Yao-Cheng

  Department of Pharmacology, School of Pharmacy, Second Military Medical University

• CHEN Wan-Sheng

  Department of Pharmacy, Changzheng Hospital

• Rui Yao-cheng

  Department Of Pharmacology School Of Pharmacy Second Military Medical University

• Chen Wan-sheng

  Department Of Pharmacy Changzheng Hospital

• Qiu Yan

  Department Of Pharmacology School Of Pharmacy Second Military Medical University

• Mao Jun-qin

  Department Of Pharmacy 85 Hospital

• Yang Peng-yuan

  Department Of Chemistry & Institutes Of Biomedical Sciences Fudan University

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