Epithelial cell proliferation in the odontogenic keratocyst : a review

概要

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Odontogenic cysts have in common an origin from the tissues of tooth formation, with the majority of them occurring within the jaws. Despite considerable effects, little is known about the biological processes governing the initiation and growth of these lesions, particularly those of 'developmental' origin, I.e. odontogenic keratocysts, lesions are the most difficult to treat surgically and quite often recur. The proposed histogenic differences and the clinically more aggressive nature of odontogenic keratocyst (OKC) in comparison with that of other odontogenic cysts has prompted studies aimed at characterizing possible differences between their fluid aspirates, connective tissue walls, and epithelial linings. In the light of recent developments and current opinion, this paper intended to review a variety of research interests which have concentrated on, or related to, cell kinetics and differentiation of the OKC epithelium. Such studies have provided a great deal of useful information, and at the same time, raised new questions with respect to our present understanding of this clinically important entity.
1997-03-25