1型糖尿病とバセドウ病を同時期に診断しえた多腺性自己免疫症候群の2例

概要

論文の詳細を見る
Case 1 : A 31-year-old woman admitted after reporting thirst for a month was found in laboratory data to have fasting plasma glucose of 219 mg/d/, HbAic of 8.8%, positive anti-GAD antibody, plasma TSH below 0.01 ﾎｼU/ml, normal free triiodothyronine and thyroxine, and positive TSH receptor antibody. Case 2 : A 51-year-old woman with diabetes mellitus treated with oral hypoglycemic agent for 2 months and admitted for glycemic control was found in laboratory data to have HbAic of 9.2%, urinary C-peptide secretion of 12 ﾎｼg/day, positeve anti-GAD antibody, plasma TSH below 0.01 ﾎｼU/ml, high free triiodothyronine and thyroxine, and positive thyroid stimulating antibody. Both were diagnosed as having simultaneous type 1 diabetes mellitus and Graves' disease, i.e., type III polyglandular autoimmune (PGA) syndrome. HLA examination showed that case 1 had HLA B6l , DR9, and DRB1*0901-DQB1*0303 associated with type 1 diabetes. Case 2 had HLA DQB1*0601 and DQB1*0401, the former sensitive and the second a resistant allele in typel diabetes. The difference in HLA antigen may influence the difference in incidence.
日本糖尿病学会 = Japan Diabetes Societyの論文
2008-04-30