Fluorine-19 Fast Recovery Fast Spin Echo Imaging for Mapping 5-Fluorouracil
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概要
- 論文の詳細を見る
We investigated the effects of fast recovery (FR) to increase the sensitivity of fluorine-19 (19F) fast spin echo (FSE) in mapping 5-fluorouracil (5-FU) and its metabolites. We added an additional 90° pulse (which flips back longitudinal magnetization at the end of the sequence) to the chemical shift selective 19F FSE pulse sequence. In 5-FU solution, FR remarkably improved the signal-to-noise (S/N) ratio of 19F 5-FU images, having higher effects with shorter repetition time and smaller echo train numbers. In animal studies, FR produced a conspicuous increase in 19F signals in the urinary bladder. FR effects for 19F signals in the liver were smaller than those in other organs but still substantial. Utilization of FR in 19F FSE images promises more sensitive observation of 19F metabolite maps of 5-FU and other 19F-containing compounds that have relatively long relaxation times.
- 日本磁気共鳴医学会の論文
- 2007-12-31
著者
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Morikawa Shigehiro
Biomedical MR Science Center, Shiga University of Medical Science
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Morikawa Shigehiro
滋賀医科大学 外科
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Morikawa Shigehiro
Biomedical Mr Science Center Shiga University Of Medical Science
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INUBUSHI Toshiro
Biomedical MR Science Center, Shiga University of Medical Science
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MORITA Masahito
Biomedical MR Science Center, Shiga University of Medical Science
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Tooyama Ikuo
Molecular Neuroscience Research Center, Shiga University of Medical Sciencev
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Morikawa Shigehiro
Mr Science Research Center Shiga University Of Medical Science
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MURAKAMI Koichiro
Biomedical MR Science Center, Shiga University of Medical Science
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MASUDA Chiaki
Molecular Neuroscience Research Center, Shiga University of Medical Science
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MAKI Jun-ichi
Molecular Neuroscience Research Center, Shiga University of Medical Science
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Maki Jun-ichi
Molecular Neuroscience Research Center Shiga University Of Medical Science
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Inubushi Toshiro
Biomedical Mr Science Center Shiga University Of Medical Science
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Murakami Koichiro
Department Of Surgery Shiga University Of Medical Science
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Tooyama Ikuo
Molecular Neuroscience Research Center Shiga University Of Medical Science
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Masuda Chiaki
Molecular Neuroscience Research Center Shiga University Of Medical Science
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Morita Masahito
Biomedical Mr Science Center Shiga University Of Medical Science
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Morikawa Shigehiro
Department Of Surgery Shiga University Of Medical Science
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Morikawa Shigehiro
Biomedical Mr Science Research Center Shiga University Of Medical Science
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Inubushi Toshiro
Biomedical Mr Science Research Center Shiga University Of Medical Science
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Murata Satoshi
Biomedical Mr Science Center Shiga University Of Medical Science
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TOOYAMA Ikuo
Molecular Neuroscience Research Center, Shiga University of Medical Science
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