Deposition of Alpha2-Macroglobulin in Fibrillar Type of Senile Plaques in the Brain of PS/APP-Transgenic Mice
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概要
- 論文の詳細を見る
Alpha2-macroglobulin (A2M), a pan-proteinase inhibitor, accumulates in senile plaques of Alzheimer disease. In this study, we investigated the immunohistochemical localization of A2M in the brain of PS/APP mice. In control mice, A2M immunoreactivity was restricted to the vessels of brain parenchyma. In PS/APP mice, A2M deposition occurred in the brain parenchyma. A2M-positive deposits appeared after three months of age when senile plaque formation began to occur. The number of A2M-positive deposits increased with age. Double-staining for A2M and thioflavin S revealed that A2M accumulated in a subpopulation of thioflavin S-positive fibrillar type of amyloid beta deposits. These results indicate that A2M is implicated in the formation of fibrillar type senile plaques in PS/APP mice.
- 日本組織細胞化学会の論文
著者
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Kondo Tetsuo
Department Of Pathology Interdisciplinary Graduate School Of Medicine And Engineering University Of
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Tooyama Ikuo
Molecular Neuroscience Research Center, Shiga University of Medical Sciencev
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Tooyama I
Molecular Neuroscience Research Center Shiga University Of Medical Science
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Tooyama Ikuo
Molecular Neuroscience Research Center Shiga University Of Medical Science
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Kondo Y
Molecular Neurobiology Research Center Shiga University Of Medical Science
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Kondo Takayuki
Molecular Neurobiology Research Center, Shiga University of Medical Science
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Kondo Takayuki
Molecular Neurobiology Research Center Shiga University Of Medical Science
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Kondo Tetsuo
Department Of Pathology Yamanashi Medical University
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