Combination of two fat saturation pulses improves detectability of glucose signals in carbon-13 MR spectroscopy
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概要
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In order to improve the fat suppression performance of in vivo 13C-MRS operating at 3.0 Tesla, a phantom model study was conducted using a combination of two fat suppression techniques; a set of pulses for frequency (chemical shift) selective suppression (CHESS), and spatial saturation (SAT). By optimizing the slab thickness for SAT and the irradiation bandwidth for CHESS, the signals of the –13CH3 peak at 49 ppm and the –13CH2– peak at 26 ppm simulating fat components were suppressed to 5% and 19%, respectively. Combination of these two fat suppression pulses achieved a 53% increase of the height ratio of the glucose C1β peak compared with the sum of all other peaks, indicating better sensitivity for glucose signal detection. This method will be applicable for in vivo 13C-MRS by additional adjustment with the in vivo relaxation times of the metabolites.(Communicated by Masanori OTSUKA, M.J.A.)
著者
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Inubushi Toshiro
Biomedical Mr Science Center Shiga University Of Medical Science
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Matsuda Tsuyoshi
Application Research Department Ge Yokogawa Medical Systems Ltd.
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TOMIYASU Moyoko
Research Program for Carbon Ion Therapy and Diagnostic Imaging, Research Center for Charged Particle
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TROPP James
Global Applied Sciences Lab, GE Healthcare Corporation
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NAKAI Toshiharu
Neuroimaging and Informatics Lab, Division of Gerontechnology, National Center for Geriatrics and Ge
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Nakai Toshiharu
Neuroimaging & Informatics Lab Department Of Gerontechnology National Center For Geriatrics And Gerontology
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TOMIYASU Moyoko
Research Program for Carbon Ion Therapy and Diagnostic Imaging, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
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NAKAI Toshiharu
Neuroimaging and Informatics Lab, Division of Gerontechnology, National Center for Geriatrics and Gerontology
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