Suppressive Effect of Defatted Kiwi Fruit Seed Extract on Acute Inflammation and Skin Pigmentation
スポンサーリンク
概要
- 論文の詳細を見る
While kiwi fruit seeds are ingested with sarcocarps, biological activities associated with these seeds have not been examined. We evaluated the effects of the extract of defatted kiwi fruit seeds (KSE) on inflammation and melanin production. In a mouse writhing model stimulated by acetic acid, KSE (100-400mg/kg) suppressed the increase in abdominal capillary permeability in a dose-dependent manner. KSE inhibited lipopolysaccharide-induced prostaglandin (PG) E2 production, but not nitric oxide (NO) production from RAW264 cells. Quercitrin and kaempferol 3-O-rhamnoside, flavonol glycosides isolated from KSE, suppressed PG E2 and NO production only at high concentrations (100μg/mL). Hence, contribution of these compounds to the inhibitory activity of KSE appeared to be low. KSE, quercitrin, and kaempferol 3-O-rhamnoside showed inhibitory effects on tyrosinase activity and melanin production in B16 melanoma cells. However, daily oral administration of KSE (200-800mg/kg) for 24 days did not affect melanin production induced by ultraviolet ray (UV)-B irradiation ; instead, it enhanced the disappearance of pigmentation in the guinea pig skin. Consequently, KSE was found to suppress acute inflammation and enhance melanin disappearance. Although flavonol glycosides suppressed melanin production in vitro, their involvement in anti-inflammatory activity and melanin disappearance of KSE was not clarified.
- 社団法人 日本食品科学工学会の論文
- 2007-11-01
著者
-
KASAJIMA Naoki
School of Pharmacy, Shujitsu University
-
SHIMODA Hiroshi
Research and Development Division, Morishita Jintan Co., Ltd.
-
TANAKA Junji
Research & Development Division, Oryza Oil & Fat Chemical Co., Ltd.
-
Shimoda Hiroshi
Research & Development Division Oryza Oil & Fat Chemical Co. Ltd.
-
Tanaka Junji
Research & Development Division Oryza Oil & Fat Chemical Co. Ltd.
-
Kasajima Naoki
School Of Pharmacy Shujitsu University
-
SHAN Shao-Jie
Research & Development Division, Oryza Oil & Fat Chemical Co., Ltd.
-
Shan Shao-jie
Research & Development Division Oryza Oil & Fat Chemical Co. Ltd.
-
Shimoda Hiroshi
Oryza Oil & Fat Chemical Co. Ltd. Aichi Jpn
-
Tanaka Junji
Oryza Oil & Fat Chemical Co. Ltd. Aichi Jpn
関連論文
- Urinary Excretion of Anthocyanins in Humans after Cranberry Juice Ingestion
- Cypellogins A, B and C, Acylated Flavonol Glycosides from Eucalyptus cypellocarpa
- Hepatoprotective and Antioxidative Properties of Salacia reticulata : Preventive Effects of Phenolic Constituents on CCl_4-Induced Liver Injury in Mice
- Anti-Obesity and Hypotriglyceridemic Properties of Coffee Bean Extract in SD Rats
- Suppressive Effect of Defatted Kiwi Fruit Seed Extract on Acute Inflammation and Skin Pigmentation
- POTENT IMMUNOSUPPRESSIVE PRINCIPLES, DIMERIC SESQUITERPENE THIOALKALOIDS, ISOLATED FROM NUPHARIS RHIZOMA, THE RHIZOMA OF NUPHAR PUMILUM (NYMPHAEACEAE) : STRUCTURE-REQUIREMENT OF NUPHAR-ALKALOID FOR IMMUNOSUPPRESSIVE ACTIVITY
- Nucleophilic aminomethylation of aldehydes with .ALPHA.-amino alkylsilanes.
- Reactions of 1,4-bis(trimethylsilyl)-1,4-dihydropyridines with carbonyl compounds : A new method for regioselective synthesis of 3-alkylpyridines.