ファージ提示技術によるオリゴ糖鎖を認識する分子の同定

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概要

• 論文の詳細を見る

• 複合糖質に結合する分子は糖鎖研究および糖鎖の関連する病気に大きく貢献できる。しかし糖質の低い免疫原性のため、目的の糖鎖に結合する抗体を得ることは容易ではない。近年のファージ提示技術により、膨大な候補の中から効率的に糖鎖特異的な分子を得ることができるようになった。これまでにペプチドライブラリー、抗体ライブラリー、変異レクチンライブラリーなどの様々なライブラリーが適用されている。このシステムを用いれば、我々の必要な親和性や特異性を持つ糖鎖結合分子を設計することができるだろう。

• FCCA(Forum: Carbohydrates Coming of Age)の論文
• 2007-05-02

著者

• Sato Toshinori

  Department Of Biosciences And Informatics Faculty Of Science And Technology Keio University

• Matsubara Teruhiko

  Department Of Bioscience And Biotechnology Faculty Of Engineering Okayama University

• Matsubara Teruhiko

  Department Of Biosciences And Informatics Faculty Of Science And Technology Keio University

• Sato Toshinori

  Department Of Artificial Intelligence Kyushu Institute Of Technology

• Sato Toshinori

  Department of Applied Chemistry, Keio University

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