構造プロテオミクス科学時代の放射光結晶学

概要

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Synchrotron light has brought unprecedented progress in the protein crystallographic studies of macromolecules during the last two decades. The high brilliance and the wavelength tunability are the two key characteristics of the modern synchrotron light sources, but the coordinated effort in providing seamless experimental environments on the experimental stations have proven to be equally important for competitive structural biology research. The advancements did not happen alone but have been made possible by synergy between the synchrotron facilities and users whose high demands kept the former busy in developing new methodologies such as low energy SAD phasing, and other high-throughput techniques. This review summarizes the recent advancements of synchrotron radiation protein crystallography and highlights of structural biology results in the protein transport and posttranslational modification with an overview of whats ahead in the synchrotron light based protein crystallography.
2005-12-27