Porphyromonas gingivalis の扁桃投与による特異的唾液 IgA の誘導

概要

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Recent reports show that tonsillar application is a more effective method to induce specific IgA in saliva than nasal application or intragastric instillation. In the case of the tonsillar application of Gram-positive and cariogenic streptococci, Streptococcus mutans, the antibody which intensively and selectively reacts against S. mutans is induced in saliva. The purpose of this study is to examine the efficiency of the salivary IgA induction using Gram-negative and periodontogenic rods, Porphyronomas gingivalis, as an antigen. At the sixth week after tonsillar application, anti-P. gingivalis agglutination titers and anti-P. gingivalis immunoglobulin concentrations of saliva and blood plasma greatly increased. The numbers of anti-P. gingivalis IgA-producing cells in parotid glands after tonsillar application also increased at the sixth week. Salivary IgA induced by tonsillar application reacted with allogenic strain of P. gingivalis and did not react with other bacteria including Prevotella intermedia, Fusobacterium nucleatum, and S. sanguis. The results show that tonsillar application induces salivary IgA which intensively and selectively reacts against P. gingivalis.
九州歯科学会の論文
1998-10-25