The Role of the DRY Motif of Human MC4R for Receptor Activation
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概要
- 論文の詳細を見る
We constructed several mutant human MC4R cDNAs by site directed mutagenesis and expressed these receptors in COS-1 cells. The conserved DRY motif among GPCRs was mutated to generate eight mutants. While no MC4R ligand binding was detected in any of the mutants, one mutant, D146A, resulted in higher cAMP production in cells than the wild-type receptor without ligand stimulation.
- 社団法人 日本農芸化学会の論文
- 2004-06-23
著者
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MORISHIMA Isao
Department of Biochemistry and Biotechnology, Faculty of Agriculture, Tottori University
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Morishima Isao
Dep. Of Biochemistry And Biotechnology Fac. Of Agriculture Tottori Univ.
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Morishima Isao
Department Of Agricultural Chemistyr Tottori University
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Morishima Isao
Department Of Biochemistry And Biotechnology Faculty Of Agriculture Tottori University
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Oshida Yuichi
Medicinal Pharmacology Laboratory Taisho Pharmaceutical Co. Ltd.
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Yamano Yoshiaki
Department Of Biochemistry And Biotechnology Faculty Of Agriculture Tottori University
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Yamano Yoshiaki
Lab. Of Veterinary Biochemistry Fac. Of Agriculture Tottori Univ.
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Yoshimizu T
Taisho Pharmaceutical Co. Ltd. Saitama Jpn
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Yoshimizu Takao
Medicinal Pharmacology Laboratory Taisho Pharmaceutical Co. Ltd.
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KAMON Rio
Department of Biochemistry and Biotechnology, Faculty of Agriculture, Tottori University
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TODA Yoshihisa
Medicinal Pharmacology Laboratory, Taisho Pharmaceutical Co., Ltd.
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CHAKI Shigeyuki
Medicinal Pharmacology Laboratory, Taisho Pharmaceutical Co., Ltd.
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YOSHIOKA Masanobu
Department of Biochemistry and Biotechnology, Faculty of Agriculture, Tottori University
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Kamon Rio
Department Of Biochemistry And Biotechnology Faculty Of Agriculture Tottori University
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Toda Yoshihisa
Medicinal Pharmacology Laboratory Taisho Pharmaceutical Co. Ltd.
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Yoshioka Masanobu
Department Of Biochemistry And Biotechnology Faculty Of Agriculture Tottori University
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Chaki Shigeyuki
Medicinal Pharmacology Laboratory Taisho Pharmaceutical Co. Ltd.
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MORISHIMA Isao
Department of Agricultural Chemistry, Tottori University
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MORISHIMA Isao
Department of Agricultural Chemistry, Faculty of Agriculture, University of Tottori
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