Synthesis of (3R, 4S)-3, 4, 5-Trihydroxy-4-methylpentylphosphonic Acid as a Potential Inhibitor of the Nonmevalonate Pathway
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概要
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The nonmevalonate pathway is widely found in higher plants and in many eubacteria, including pathogenic ones, but not in mammals. Identifying a nonmevalonate pathway inhibitor would greatly contribute to the search for new herbicides and antibacterial drugs to treat, for example, malaria. We describe here the synthesis of (3R,4S)-3,4,5-trihydroxy-4-methylpentylphosphonic acid as a candidate for inhibiting MEP cytidylyltransferase, which is the third step on the nonmevalonate pathway.
- 2004-06-23
著者
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YOSHIOKA Toshiaki
Graduate School for Environmental Studies, Tohoku University
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OHRUI Hiroshi
Graduate School of Life Science, Tohoku University
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SHIMIZU Hiroki
Graduate School of Life Sciences, Tohoku University
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Yoshioka Toshiaki
Graduate School For Environmental Studies Tohoku University
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Shimizu H
Graduate School Of Life Sciences Tohoku University
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Shimizu Hiroki
Graduate School Of Life Sciences Tohoku University
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Ohrui Hiroshi
Graduate School Of Life Science Tohoku University
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Yoshioka Toshiaki
Graduate School Of Life Sciences Tohoku University
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