Comparative Study of [^3H]Ramosetron and [^3H]Granisetron Binding in the Cloned Human 5 : Hydroxytryptamine_3 Receptors
スポンサーリンク
概要
- 論文の詳細を見る
Characteristics of the binding of [3H]ramosetron to cloned human 5-hydroxytryptamine3 (5-HT3) receptors were investigated and directly compared to those of [3H]granisetron binding. Saturation studies revealed that [3H]ramosetron labeled more sites with high affinity (Kd=0.15±0.01 nM, Bmax=653±30 fmol/mg protein) than [3H]granisetron (Kd=1.17±0.25 nM, Bmax=427±43 fmol/mg protein). Kinetic studies revealed that dissociation of [3H]ramosetron was slower than that of [3H]granisetron. These results suggest that ramosetron is a highly potent 5-HT3-receptor antagonist.
- 社団法人 日本薬理学会の論文
- 1998-11-01
著者
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Yamaguchi Tokio
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Yamaguchi Tokio
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Yamaguchi Tokio
Neuroscience Research Pharmacology Laboratiries Institute For Drug Discavery Research Yamanouchi Pha
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Akuzawa Shinobu
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Akuzawa Shinobu
Neuroscience And Gastrointestinal Research Laboratories Institute For Drug Discovery Research Yamano
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ITO Hiroyuki
Neuroscience Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi
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Ito Hiroyuki
Neuroscience And Gastrointestinal Research Laboratory Institute For Drug Discovery Research Yamanouc
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Ito Hiroyuki
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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