Neuroprotective Effect of YM-39558, Orotic Acid Ethylester, in Gerbil Forebrain Ischemia
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概要
- 論文の詳細を見る
We studied the effects of orotic acid and YM-39558 (2, 6-dioxo-1, 2, 3, 6-tetrahydropyrimidine-4-carboxylic acid ethyl ester), orotic acid ethylester, on delayed neuronal death of hippocampal CA1 neurons induced by transient forebrain ischemia. Our data indicated that YM-39558 had high permeability across the blood brain barrier and was hydrolyzed to orotic acid, the active substance, in the brain. The neuronal damage was reduced significantly in animals intraperitoneally treated with YM-39558 (100 mg/kg×3) after ischemia, but not with orotic acid in the same way. The results also suggested that the maintenance of a few ten micromolar orotic acid in cerebrospinal fluid were needed for its neuroprotective effects.
- 社団法人 日本薬理学会の論文
- 1998-04-01
著者
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Yamaguchi T
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Yamaguchi Tokio
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Yamaguchi Tokio
Neuroscience Research Pharmacology Laboratiries Institute For Drug Discavery Research Yamanouchi Pha
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AKIHO Hiraku
Neuroscience Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi
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IWAI Akihiko
Neuroscience Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi
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KATOH-SUDOH Mika
Neuroscience Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi
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TSUKAMOTO Shin-ichi
Neuroscience Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi
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KOSHIYA Kazuo
Neuroscience Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi
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Katoh-sudoh Mika
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Iwai Akihiko
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Akiho Hiraku
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Koshiya K
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Koshiya Kazuo
Neuroscience Research Pharmacological Laboratory Institute For Drug Discovery Research Yamanouchi Ph
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Tsukamoto Shin-ichi
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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