The AMPA-Receptor Antagonist YM90K Reduces AMPA Receptor-Mediated Excitotoxicity in Rat Hippocampal Cultures
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概要
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The effects of YM90K on α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-mediated excitotoxicity were investigated using kainate, AMPA and cyclothiazide in rat hippocampal cultures. YM90K had neuroprotective actions against both kainate toxicity and cyclothiazideenhanced AMPA toxicity. YM90K induced a parallel and rightward shift of both kainate and AMPA dose-response curves. The application of YM90K even 3 hr after the start of kainate exposure significantly reduced kainate toxicity. These results indicate that YM90K protects neurons against AMPA receptor-mediated toxicity at an agonist site on the AMPA receptor and that YM90K protects against AMPA receptor-mediated toxicity even if applied after neurotoxic insult.
- 社団法人 日本薬理学会の論文
著者
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Yamaguchi T
Neuroscience Research Pharmacology Laboratiries Institute For Drug Discavery Research Yamanouchi Pha
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Yamaguchi Tokio
Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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Tsutsumi Rie
Neuroscience Research Pharmacology Laboratiries Institute For Drug Discavery Research Yamanouchi Pha
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Yamaguchi Tokio
Neuroscience Research Pharmacology Laboratiries Institute For Drug Discavery Research Yamanouchi Pha
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Ohno K
Nissin Food Products Co. Ltd. Shiga Jpn
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Okada Masamichi
Neuroscience Research Pharmacology Laboratiries Institute For Drug Discavery Research Yamanouchi Pha
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OHNO Kazushige
Neuroscience Research, Pharmacology Laboratiries, Institute for Drug Discavery Research, Yamanouchi
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SAKAMOTO Shuichi
Neuroscience Research, Pharmacology Laboratiries, Institute for Drug Discavery Research, Yamanouchi
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Sakamoto Shuichi
Neuroscience Research Pharmacology Laboratiries Institute For Drug Discavery Research Yamanouchi Pha
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Tsutsumi Rie
Neuroscience & Gastrointestinal Research Laboratory, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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