Effect of YM992,a Novel Antidepressant With Selective Serotonin Re-uptake Inhibitory and 5-HT_<2A> Receptor Antagonistic Activity, on a Marble-Burying Behavior Test as an Obsessive-Compulsive Disorder Model

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概要

• 論文の詳細を見る

• YM992 ((S)-2-[[(7-fluoroindan-4-yl)oxy]methyl]morpholine) monohydrochloride is a novel antidepressant with selective serotonin (5-hydroxytryptamine, 5-HT) re-uptake inhibition and 5-HT2A receptor antagonistic activity. The effects of YM992 and two selective 5-HT re-uptake inhibitors (SSRIs) were studied in a marble-burying behavior test as a model of an obsessive-compulsive disorder (OCD) in mice at doses of 5, 10 and 15 mg/kg, i.p. YM992 and fluoxetine significantly inhibited marble-burying behavior at a dose of 15 mg/kg (i.p.) without affecting spontaneous locomotor activities. Citalopram also significantly inhibited the behavior at doses of 5, 10 and 15 mg/kg (i.p.) without affecting spontaneous locomotor activities. These results suggest that YM992, as well as SSRIs, may exhibit anti-OCD activity in addition to an antidepressive effect in clinical use.

• 社団法人 日本薬理学会の論文
• 2002-10-01

著者

• Yamaguchi Tokio

  Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha

• Yamaguchi Tokio

  Neuroscience Research Pharmacology Laboratiries Institute For Drug Discavery Research Yamanouchi Pha

• YATSUGI Shin-ichi

  Neuroscience Research, Pharmacological Laboratory, Institute for Drug Discovery Research, Yamanouchi

• TAKEUCHI Hiromi

  Neuroscience Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi

• Yatsugi Shin-ichi

  Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha

• Takeuchi Hiromi

  Neuroscience Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha

• Yatsugi Shin-ichi

  Neuroscience Research Pharmacological Laboratory Institute For Drug Discovery Research Yamanouchi Ph

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• Effect of YM992,a Novel Antidepressant With Selective Serotonin Re-uptake Inhibitory and 5-HT_ Receptor Antagonistic Activity, on a Marble-Burying Behavior Test as an Obsessive-Compulsive Disorder Model

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