Quenching of Nitric Oxide by an Oral Carbonaceous Adsorbent
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概要
- 論文の詳細を見る
The ability of carbonaceous particles (AST-120), originally developed as an enteral adsorbent of uremic toxins, to quench nitric oxide (NO)was tested. NO in solutions prepared by two methods [NO gas bubbling and NO generating system, i.e., decomposition of 1-hydroxy-2-oxo-3-(aminopropyl)-3-isopropyl1-triazene] were determined by a NO-specific reduction of carboxy-2-phenyl-4, 4, 5, 5-tetramethyl-imidazoline-l-oxyl-3-oxide using an electron paramagnetic resonance spectrometry. NO concentrations were less in samples containing increasing concentrations of AST-120. In a separate study, nitrite concentrations in lipopolysaccharide-treated RAW264 cells were significantly less in incubation medium containing AST-120. Thus, AST-120 may be applicable as an enteral anti-NO agent.
- 社団法人 日本薬理学会の論文
- 1997-06-01
著者
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Ito Katsumi
Department Of Rheumatology And Orthopaedic Surgery Yugawara Kosei-nenkin Hospital
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Ito K
Miyazaki Univ. Miyazaki Jpn
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Iwamoto Noriko
Department Of Pediatric Nephrology Kidney Center
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Yoshioka Toshimasa
Department Of Medical Eudcation Tokyo Women's Medical University School Of Medicine
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Yoshioka Toshimasa
Department Of Pediatric Nephrology Kidney Center
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KAKUCHI Junji
Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd.
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Kakuchi Junji
Biomedical Research Laboratories Kureha Chemical Industry Co. Ltd.
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Ito Katsumi
Department Of Pediatric Nephrology Kidney Center Tokyo Women's Medical College
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Yoshioka Toshimasa
Department Of Medical Education Tokyo Women's Medical University
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