DNA Vaccines

スポンサーリンク

概要

• 論文の詳細を見る

• DNA vaccination or genetic immunization is a rapidly developing technology that offers new approaches for the prevention and therapy of disease.Regarding the inoculation method of DNA vaccine, we recommend the gene gun delivery system, which is a highly reliable method compared to intramuscular inoculation.DNA vaccines could have potential advantages over other types of vaccines in that these vaccines can induce strong cellular immune responses, cytotoxic T lymphocytes and type 1 helper T cells, without resorting to live organisms or complicated protein formulation.The cellular immune responses are especially required for the protection against infections with intracellular pathogens such as viruses and Mycobacterium tuberculosis and protection against cancers, suggesting that they seem to be suitable targets of DNA vaccines.We describe here that their application to bacterial infections requires optimization of codon usage in the DNA vaccines to the host animal to improve translational efficiencies of the bacteria genes.DNA vaccines for a variety of pathogens and cancers have now entered phase I/II human clinical trials.

• 社団法人 日本薬理学会の論文
• 2000-07-01

著者

• Yoshida Atsushi

  Department of Sagami Junkannki Clinic, Kitasato University School of Medicine

• Nagata Toshi

  Department Of Microbiology And Immunology Hamamatsu University School Of Medicine

• Nagata Toshi

  Department Of Chemistry Faculty Of Science Kyoto University

• Koide Yukio

  Department Of Electrical Engineering

• Koide Y

  Hamamatsu Univ. School Of Medicine Hamamatsu Jpn

• UCHIJIMA Masato

  Department of Microbiology and Immunology, Hamamatsu University School of Medicine

• Uchijima Masato

  Department Of Microbiology And Immunology Hamamatsu University School Of Medicine

• Yoshida Atsushi

  Department Of General Infectious Diseases Dokkyo Medical University Hospital

• Yoshida Atsushi

  Department Of Breast Surgery St. Luke's International Hospital

• Uchijima Masato

  Department of Chemistry, Faculty of Science, Kochi University

• Nagata Toshi

  Department of Applied Chemistry, Faculty of Science and Technology, Meijo University

関連論文

• Clinical features and subdural lesions in childhood onset Haemophilus influenzae meningitis
• Spontaneous Remission of Secondary Hyperparathyroidism due to Hemorrhagic Infarction in a Uremic Patient Undergoing Maintenance Hemodialysis
• Video-Assisted Thoracic Surgery Lobectomy for Extralobar Pulmonary Sequestration in a Child : Report of a Case
• Effects of RGD Peptides on Cells Derived From the Human Eye
• Application of loop-mediated isothermal amplification technique to rapid and direct detection of methicillin-resistant Staphylococcus aureus (MRSA) in blood cultures
• ULTRASONOGRAPHIC STUDIES ON PLACENTOGRAPHY AND ITS CLINICAL EVALUATION
• ULTRASONOGRAPHIC STUDIES ON FIRST PREGNANCY FOLLOWING MOLAR PREGNANCY
• Fractal Characters of 1/2-order Integration of White Noise and 1/f Resistance Fluctuation
• Does increased nuchal translucency indicate a fetal abnormality? A retrospective study to clarify the clinical significance of nuchal translucency in Japan
• Precise Measurement of the Gamma-ray Emission Probabilities for ^In with Half-life of 54. 15 min
• Neuroblastoma detected by mass screening : the Tumor Board's role in its treatment
• B-03 The development of chemistry curriculum for Upper Secondary school in Cambodia
• The Effect of Immunization with Herpes Simplex Virus Glycoprotein D Fused with Interleukin-2 against Murine Herpetic Keratitis
• Influence of Angular Position and Degree of Impaction of Third Molars on Development of Symptoms : Long-Term Follow-up under Good Oral Hygiene Conditions
• Synthesis and Electrochemical Properties of Dinuclear Manganese(II) Complexes with Octadentate Schiff-base Macrocycles. Fine Tuning of the Redox Behavior
• Analysis of Pathogenesis of Autoimmune Insulitis in NOD Mice: Adoptive Transfer Experiments of Insulitis in ILI and NOD Nude Mice
• Mutual Inductance between the Semicircular Bus and the Straight Bus (III)
• Mutual Inductance between the Semicircular Bus and the Straight Bus (II)
• Mutual Inductance between the Semicircular Bus and the Straight Bus (I)
• Case of Bilateral Multiple Herpetic Epithelial Keratitis Manifested as Dendriform Epithelial Edema During Primary Kaposi's Varicelliform Eruption
• DNA Vaccines
• cDNAクロ-ニングによる8細胞期マウス胚におけるH-2K mRNAの検出〔英文〕
• Synthesis and Properties of New, Spatially Relaxed Dendrons Containing Internal Carboxyl Groups
• The role of basic fibroblast growth factor to enhance fetal intestinal mucosal cell regeneration in vivo
• Radiographic features for triple negative ductal carcinoma in situ of the breast
• Differential recruitment of CD63 and Rab7-interacting-lysosomal-protein to phagosomes containing Mycobacterium tuberculosis in macrophages
• GENDER ISSUES IN SCIENCE EDUCATION IN JAPAN
• Correlation Between Preeclampsia and Prevalence of Polymorphism of Angiotensinogen, Methyleneteterahydrofolate Reductase and Factor V, Prothrombin Genes Among Japanese Women
• Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer
• Serum HER2 levels determined by two methods in patients with metastatic breast cancer
• Clinical application of fetal sex determination using cell-free fetal DNA in pregnant carriers of X-linked genetic disorders
• Estimation of Surface Recombination Velocity from Thickness Dependence of Carrier Lifetime in n-Type 4H-SiC Epilayers
• Structure and Deposition Mechanism of 10-Undecenoic Acid Self-Assembled Layers on H-Si (111) Surfaces Studied by Atomic Force Microscopy and Fourier-Transform Infrared
• Clinical background comparison of patients with and without ocular inflammatory attacks after initiation of infliximab therapy
• Successful Vancomycin Desensitization with a Combination of Rapid and Slow Infusion Methods
• Xanthogranulomatous Cholecystitis Mimicking Gallbladder Cancer; Report of a Case.:Report of a Case
• Appendicitis Caused by Caecal Carcinoma: Report of a Case.
• Metal complexes of peptides. IV. Cobalt(III) complexes with .BETA.-alanyl-L-histidine (carnosine) functioning as a quadridentate ligand.
• 3D Anatomical Variations of Hepatic Vasculature and Bile Duct for Right Lateral Sector of Liver with Special Reference to Transplantation
• Laterality of the Corticospinal Tract and the Influence of Handedness : Findings of a DTI Study
• Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer

もっと見る 閉じる

スポンサーリンク