Successful Vancomycin Desensitization with a Combination of Rapid and Slow Infusion Methods
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概要
- 論文の詳細を見る
Vancomycin, an antibiotic to which methicillinresistant Staphylococcus aureus (MRSA) is sensitive, frequently induces hypersensitivity reactions. Lowering the vancomycin infusion rate and/or premedicating with antihistamine effectively reduce hypersensitivity in most cases. However, vancomycin desensitization is sometimes the only way to ensure safe use. Two types of desensitization protocols have been reported, and these utilize different infusion intervals; rapid desensitization and slow desensitization. We herein report a case of vancomycin hypersensitivity with methicillinresistant Staphylococcus aureus infection. A combination of the two desensitization protocols, rapid desensitization followed by slow desensitization, effectively inhibited the hypersensitivity reaction during vancomycin infusion, and methicillinresistant Staphylococcus aureus was successfully eradicated.
- 社団法人 日本内科学会の論文
著者
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Kada Nanae
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Ota Yasuo
Depart.of International Agril.development Tokyo University Of Agriculture
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Koike Kazuhiko
Department Of Environmental And Public Health Sapporo Medical College
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Kimura Satoshi
Department Of Anesthesiology And Critical Care Medicine Kasugai Municipal Hospital
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Kitazawa Takatoshi
Department Of Infectious Diseases Graduate School Of Medicine The University Of Tokyo
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Yoshida Atsushi
Department Of Breast Surgery St. Luke's International Hospital
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MORISAWA Yuji
Department of Infection Prevention and Control, Jichi Medical University
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