TIME DEPENDENT EFFECTS OF SELENIUM ON CADMIUM-INDUCED AUTE MOUSE TESTICULAR DAMAGE
スポンサーリンク
概要
- 論文の詳細を見る
Twenty-four hr after a single subcutaneous injection of Cd (0.024 mmo1/kg), the testis showed severe and widespread degeneration. The damage was accompanied by an increase of lipoperoxide and a decrease of glutathione in the testis. Se (0.048 mmol/kg) injections 2 hr before, at the same time, and 1 hr after the Cd injection, decreased the damage. In these groups, the level of glutathione and lipoperoxides was restored to the control level. With a Se injection 6 hr after the Cd injection, the preventive effect of Se was no longer found. In the testis in which Se injection alleviated the damage caused by Cd, the changes in Ca, Mg and Zn were also restored to the control level. Uptake of Cd into the testis was stimulated by the Se injection. However, the uptake still remained at a low level in the testis in which the Se preventive effect was not found. These results suggest that the preventive effect of Se against testicular Cd toxicity is dependent on the interval between Cd and Se injections.
- 日本トキシコロジー学会の論文
- 1986-11-25
著者
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KOIKE Kazuhiko
Department of Marine Biochemistry, School of Marine Sciences, Kitasato University
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Wada Hideki
Department Of Research And Development Yoshida Pharmaceutical Co. Ltd.
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Wada Hideki
Department Of Biology And Geology Faculty Of Science Shizuoka University
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Taguchi Keisuke
Department of Urology, Oji General Hospital
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MIYAKE Hirotsugu
Department of Public Health, School of Medicine, Sapporo Medical University
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Taguchi K
Bayer Yakuhin Ltd. Osaka Jpn
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Wada Hideki
Department Of Environmental And Public Health Sapporo Medical College
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SUGAWARA Naoki
Department of Environmental and Public Health, Sapporo Medical College
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TSUKAKUBO Toshihiro
Department of Environmental and Public Health, Sapporo Medical College
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NIHEI Takehito
Department of Environmental and Public Health, Sapporo Medical College
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YOSHIDA Yukinari
Department of Environmental and Public Health, Sapporo Medical College
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Sugawara N
Department Of Environmental And Public Health Sapporo Medical College
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Miyake Hirotsugu
Department Of Environmental And Public Health Sapporo Medical College
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Tsukakubo Toshihiro
Department Of Environmental And Public Health Sapporo Medical College
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Nihei Takehito
Department Of Environmental And Public Health Sapporo Medical College
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Yoshida Yukinari
Department Of Environmental And Public Health Sapporo Medical College
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Taguchi Keisuke
Department Of Urology Ohji General Hospital
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Koike Kazuhiko
Department Of Gastroenterology Graduate School Of Medicine
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Koike Kazuhiko
Department Of Environmental And Public Health Sapporo Medical College
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