Protective Effect of Neurotropin Against Lipopolysaccharide-Induced Hypotension and Lethality Linked to Suppression of Inducible Nitric Oxide Synthase Induction
スポンサーリンク
概要
- 論文の詳細を見る
Neurotropin is a non-protein extract from the dermis of rabbits inoculated with vaccinia virus and has been clinically used as an analgesic in Japan. We present in the current report evidence for its potential therapeutic value against endotoxin shock. Administration of this compound prior to lipopolysaccharide (LPS) challenge resulted in a reversal of a decrease of the mean arterial pressure in rats and also amelioration of lethality in mice. Anti-inducible nitric oxide synthase (iNOS) Western blotting of tissue extracts from LPS-treated mice revealed almost complete suppression of iNOS induction by Neurotropin. The findings in vivo were reproduced in in vitro experiments in which cultured human umbilical vascular endothelial cells were challenged with LPS. Simultaneous treatment of the cells with Neurotropin resulted in complete suppression of iNOS induction and significant reduction of cell death. These results suggested a therapeutic value of Neurotropin in the treatment of endotoxin shock that was linked, at least in part, to suppression of iNOS induction and reduced cell damage in vascular endothelial cells.
- 社団法人 日本薬理学会の論文
- 2001-07-01
著者
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Higaki Katsumi
Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University
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OHNO Kousaku
Department of Child Neurology, Institute of Neurological Sciences, Tottori University Faculty of Med
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NINOMIYA Haruaki
Department of Neurobiology, Tottori University Faculty of Medicine
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Ninomiya Haruaki
鳥取大学 遺伝子再生医療学
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Ninomiya H
Department Of Neurobiology Faculty Of Medicine Tottori University
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Ninomiya Haruaki
Department Of Biological Regulation Tottori University Faculty Of Medicine
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Ninomiya Haruaki
鳥取大学医学部附属脳幹性疾患研究施設 脳神経小児科部門
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Higaki Katsumi
Division Of Functional Genomics Research Center For Bioscience And Technology Tottori University
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Higaki Katsumi
鳥取大学医学部附属脳幹性疾患研究施設 脳神経小児科
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Higaki Katsumi
Department Of Neurobiology School Of Life Sciences Faculty Of Medicine Tottori University
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Higaki Katsumi
Department Of Neurobiology School Of Life Sciences Tottori University Faculty Of Medicine
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Ohno K
Division Of Child Neurology Institute Of Neurological Sciences Faculty Of Medicine Tottori Universit
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Ohno Kousaku
鳥取大学医学部附属脳幹性疾患研究施設 脳神経小児科
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Ohno K
Department Of Neurobiology School Of Life Sciences Faculty Of Medicine Tottori University
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Ohno Kousaku
Department Of Child Neurology Institute Of Neurological Sciences Faculty Of Medicine Tottori Univers
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MAKI Hirotoshi
Department of Neurobiology, School of Life Sciences, Tottori University Faculty of Medicine
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SAJI Makoto
Department of Neurobiology, School of Life Sciences, Tottori University Faculty of Medicine
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Ninomiya Haruaki
Department Of Neurobiology Faculty Of Medicine Tottori University
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Saji Makoto
Department Of Neurobiology School Of Life Sciences Faculty Of Medicine Tottori University
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Saji Makoto
Department Of Neurobiology School Of Life Sciences Tottori University Faculty Of Medicine
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Saji Makoto
Department Of Neurobiology Faculty Of Medicine And Gene Research Center Tottori University
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KOIKE Tomohiro
Department of Neurobiology, School of Life Sciences, Faculty of Medicine, Tottori University
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Ohno Kousaku
Department Of Neurobiology School Of Life Sciences Tottori University Faculty Of Medicine
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Koike Tomohiro
Department Of Neurobiology School Of Life Sciences Faculty Of Medicine Tottori University
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Maki Hirotoshi
Department Of Neurobiology School Of Life Sciences Tottori University Faculty Of Medicine
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Ohno K
日清食品食品安全研究所
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Ninomiya Haruaki
Department Of Neurobiology School Of Life Sciences Faculty Of Medicine Tottori University
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Maki Hirotoshi
Department Of Neurobiology School Of Life Sciences Faculty Of Medicine Tottori University
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Ninomiya Haruaki
Department Of Biological Regulation Faculty Of Medicine Tottori University
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