hiiragi, a gene essential for wing development in Drosophila melanogaster, affects the Notch cascade
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概要
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A recessive mutation, hiiragiP1, on the second chromosome of Drosophila was obtained by P element insertion mutagenesis. Flies homozygous for hiiragiP1 have notched wing margins. Genetic interactions between hiiragi and the genes that encode components of Notch signaling, such as Notch, Hairless, Serrate and deltex, strongly support the involvement of hiiragi in the signal transduction cascade of Notch. It has been reported that Serrate and Delta, other components of Notch signaling, share EGF-like repeats and a second conserved cysteine-rich motif, and that these components interact physically with the same region of Notch. In hiiragiP1; Serrate D/+ double mutants, we observed synergistic enhancement of the notched phenotype of wing margins. In contrast, Delta FX3 had no phenotypic effect on hiiragiP1 in hiiragiP1; DeltaFX3/+ double mutants. Taken together, these results indicate that hiiragi is involved in the Notch signaling cascade induced by Serrate rather than by Delta.
- 日本遺伝学会の論文
著者
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OKANO Hideyuki
Department of Physiology, Keio University School of Medicine
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Ogura Keiji
Tsukuba Life Science Center The Institute Of Physical And Chemical Research(riken)
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MURATA Takehide
Tsukuba Life Science Center, The Institute of Physical and Chemical Research(RIKEN)
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MURAKAMI Ryutaro
Biological Institute, Faculty of Science, Yamaguchi University
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YOKOYAMA Kazunari
Tsukuba Life Science Center, The Institute of Physical and Chemical Research(RIKEN)
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Okano Hideyuki
Department Of Neuroanatomy Biomedical Research Center Osaka University Medical School
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Murakami Ryutaro
Biological Institute Faculty Of Science Yamaguchi University
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Murata Takehide
Tsukuba Life Science Center The Institute Of Physical And Chemical Research(riken)
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Yokoyama Kazunari
Tsukuba Life Science Center The Institute Of Physical And Chemical Research(riken)
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Okano Hideyuki
Department Of Molecular Neurobiology Institute Of Basic Medical Sciences And Center For Tara(tsukuba
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