Rapid 'SAR' via Click Chemistry: An Alkyne-Bearing Spiramycin is fused with Diverse Azides to Yield New Triazole-Antibacterial Candidates
スポンサーリンク
概要
著者
-
Sunazuka T
信州大学医学部附属病院 薬剤部
-
Sunazuka Toshiaki
Kitasato Univ. Tokyo Jpn
-
Sunazuka Toshiaki
School Of Pharmaceutical Sciences Kitasato University:research Center For Biological Function The Ki
-
Hirose Tomoyasu
Kitasato Univ. Tokyo Jpn
-
NOGUCHI Yoshihiko
The Kitasato Institute, Kitasato Institute for Life Science and Graduate School of Infection Control Sciences, Kitasato University
関連論文
- 10.酢酸菌のグルコン酸酸化にかかわる第3の膜酵素・FADグルコン酸脱水素酵素(第419回研究協議会研究発表要旨,ビタミンB研究委員会)
- Total Synthesis of Malformin C, an Inhibitor of Bleomycin-Induced G2 Arrest
- 1S-Ep05 耐熱性酢酸菌を使った酸化発酵による有用物質生産系の開発(伝統的醗酵微生物の新しい利用展開,シンポジウム,伝統の技と先端科学技術の融合)
- Biochemical and Spectroscopic Properties of Cyanide-Insensitive Quinol Oxidase from Gluconobacter oxydans
- Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509 : II. Physico-chemical Properties and Structure Elucidation
- 琉球大学農学部「亜熱帯生物資源科学科,発酵・生命科学コース」と,設置予定の「泡盛学寄附講座」の紹介(九州支部,Branch Spirit)
- 2P030 酢酸菌Gluconobacter frateurii由来L-sorbose reductaseのX線結晶構造解析(蛋白質-構造機能相関,第48回日本生物物理学会年会)
- New Analogs of the Pyripyropene Family of ACAT Inhibitors via α-Pyrone Fragmentation and γ-Acylation/Cyclization
- Citrinamides, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938
- Total Synthesis of Madindolines, Potent Selective Inhibitors of Interleukine 6, Novel Bioactive Microbial Metabolites
- Chlovalicin, a New Cytocidal Antibiotic Produced by Sporothrix sp. FO-4649 II. Physicochemical Properties and Structural Elucidation
- Chlovalicin, a New Cytocidal Antibiotic Produced by Sporothrix sp. FO-4649 I. Taxon9omy, Fermentation, Isolation and Biological Activities
- Macrosphelide, a Novel Inhibitor of Cell-cell Adhesion Molecule I.Taxonomy, Fermentation, Isolation and Biological Activities
- Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083
- Reversal of Multidrug Resistance by 7-O-Benzoylpyripyropene A in Multidrug-Resistant Tumor Cells
- Madindolines, Novel Inhibitors of IL-6 Activity from Streptomyces sp. K93-0711 II. Physico-chemical Properties and Structural Elucidation
- Macrosphelides C and D, Novel Inhibitors of Cell Adhesion
- Amphistin, a New Melanogenesis Inhibitor, Produced by an Actinomycete
- Efficient Chemical Conversion of Louisianin A to C and D, The Inhibitor of Angiogenesis
- Pyridindolols K1 and K2, New Alkaloids from Streptomyces sp. K93-0711
- Madindoline, a Novel Inhibitor of IL-6 Activity from Streptomyces sp. K93-0711 I. Taxonomy, Fermentation, Isolation and Biological Activities
- A New Inhibitor of Melanogenesis, Albocycline K3, Produced by Streptomyces sp. OH-3984
- Macrosphelide, a Novel Inhibitor of Cell-cell Adhesion Molecule II. Physicochemical Properties and Structural Elucidation
- Louisianins A, B, C and D:Non-steroidal Growth Inhibitors of Testosterone-responsive SC 115 Cells II.Physico-chemical Properties and Structural Elucidation
- Louisianins A, B, C and D:Non-steroidal Growth Inhibitors of Testosterone-responsive SC 115 Cells I.Taxonomy, Fermentation, Isolation and Biological Characteristics
- The Selectivity of Beauveriolide Derivatives in Inhibition toward the Two Isozymes of Acyl-CoA: cholesterol Acyltransferase
- Selective Inhibition of Acyl-CoA : cholesterol Acyltransferase 2 Isozyme by Flavasperone and Sterigmatocystin from Aspergillus Species
- Selectivity of Pyripyropene Derivatives in Inhibition toward Acyl-CoA : cholesterol Acyltransferase 2 Isozyme
- Synthesis and Anti-platelet Aggregation Activity of Water-soluble Staurosporine Derivatives
- Inhibition of Lipid Droplet Accumulation in Mouse Macrophages by Stemphone Derivatives
- Structure-activity Relationships of Stemphones, Potentiators of Imipenem Activity against Methicillin-resistant Staphylococcus aureus
- Effect of 14-Membered Ring Macrolide Compounds on Rat Leucocyte Chemotaxis and the Structure-activity Relationships
- Effcects of Erythromycin and Its Derivatives on Interlcukin-8 Release by Human Bronchial Epithelial Cell Line BEAS-2B Cells
- Synthesis and Antiangiogenic Activity of Staurosporine Derivatives
- Chemical Modification and Structure-activity Relationships of Pyripyropenes 1. Modification at the Four Hydroxyl Groups
- Structure-activity Relationships of Pyripyropenes Fungal Acyl-CoA:Cholesterol Acyltransferase Inhibitors
- P-468 A Novel Ryanodine Binding Inhibitor, Verticilide, Produced by Verticilium sp. FKI-1033
- Andrastins A-C, New Protein Farnesyltransferase Inhibitors Produced by Penicillium sp. FO-3929 II. Structure Elucidation and Biosynthesis
- In Vitro and In Vivo Antimalarial Activities of a Carbohydrate Antibiotic, Prumycin, against Drug-resistant Strains of Plasmodia
- P-490 Total synthesis of (+)-guadinomines C, potent, selective inhibitors of Type III secretion system. Determination of the absolute configurations
- Synthesis and Biological Evaluation of a Beauveriolide Analogue Library
- Nafuredin, a Novel Inhibitor of NADH-fumarate Reductase, Produced by Aspergillus niger FT-0554
- Total Syntheses of the AChE Inhibitors (±)-Arisugacins F and G
- Determination of Absolute Stereochemistries of Arisugacin F and Territrem B, Novel Acetylcholinesterase Inhibitors
- Convergent Synthesis of Arisugacin Skeletons and Their Acetylcholinesterase Inhibitory Activity
- Structure-activity Relationships Study of Pyripyropenes : Reversal of Cancer Cell Multidrug Resistance
- Macrolides with Promotive Activity of Monocyte to Macrophage Differentiation
- Structure-activity Relationships of Lactacystin, the First Non-protein Neurotrophic Factor
- Chloropeptins, New Anti-HIV Antibiotics Inhibiting gp120-CD4 Binding from Streptomyces sp. II. Structure Elucidation of Chloropeptin I
- Three-Dimensional Structure-Activity Relationship Analysis between Motilin and Motilide Using Conformational Analysis and a Novel Molecular Superposing Method
- 4"'-N-Demethylspiramycin Derivatives : Synthesis and Evaluation of Effectiveness against Drug-resistant Bacteria
- Arisugacins C and D, Novel Acetyicholinesterase Inhibitors and Their Related Novel Metabolites Produced by Penicillium sp. FO-4259-11
- P-491 Total synthesis and determination of stereochemistry of Verticilide, an anthelmintic cyclodepsipeptide
- Kurasoins A and B, New Protein Farnesyltransferase Inhibitors Produced by Paecilomyces sp. FO-3684 II. Structure Elucidation and Total Synthesis
- A Tightly Bound Quinone Functions in the Ubiquinone Reaction Sites of Quinoprotein Alcohol Dehydrogenase of an Acetic Acid Bacterium, Gluconobacter suboxydans
- Chemical Modification and Structure-activity Relationships of Pyripyropenes 2. 1,11-Cyclic Analogs
- Total Syntheses of Kurasoins A and B,Novel Protein Farnesyltransferase Inhibitors,and Absolute Structures of Kurasoins A and B
- 耐熱性酢酸菌を使った酸化発酵による有用物質生産系の開発(伝統的発酵微生物の新しい利用展開)
- Syntheses and Absolute Structures of Novel Protein Farnesyltransferase Inhibitors, Kurasoins A and B
- Chemical Modification and Structure-activity Relationships of Pyripyropenes 3. Synthetic Conversion of Pyridine-pyrone Moiety
- Arisugacin, a Novel and Selective Inhibitor of Acetylcholinesterase from Penicillium sp.FO-4259
- Arisugacins A and B, Novel and Selective Acetylcholinesterase Inhibitors from Penicillium sp. FO-4259 II. Structure Elucidation
- Rapid 'SAR' via Click Chemistry: An Alkyne-Bearing Spiramycin is fused with Diverse Azides to Yield New Triazole-Antibacterial Candidates
- Chitinase inhibitors : extraction of the active framework from natural argifin and use of in situ click chemistry
- Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin
- New verticilides, inhibitors of acyl-CoA : cholesterol acyltransferase, produced by Verticillium sp. FKI-2679
- New isochaetochromin, an inhibitor of triacylglycerol synthesis in mammalian cells, produced by Penicillium sp. FKI-4942 : II. structure elucidation
- New isochaetochromin, an inhibitor of triacylglycerol synthesis in mammalian cells, produced by Penicillium sp. FKI-4942 : I. Taxonomy, fermentation, isolation and biological properties
- The high mannose-type glycan binding lectin actinohivin : dimerization greatly improves anti-HIV activity
- Production of monapinones by fermentation of the dinapinone-producing fungus Penicillium pinophilum FKI-3864 in a seawater-containing medium
- Dinapinones, novel inhibitors of triacylglycerol synthesis in mammalian cells, produced by Penicillium pinophilum FKI-3864
- Spoxazomicins A-C, novle antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460^T
- Solid-phase synthesis and biological activity of malformin C and its derivatives
- Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2 : II. Structure elucidation
- Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2 : I. Taxonomy, fermentation, isolation and biological properties
- Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1 : II. Structure elucidation
- Borrelidin, a potent antimalarial : stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum
- Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1 : I. Taxonomy, fermentation, isolation and biological properties
- Expression of two human acyl-CoA : diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes
- Total synthesis of amidepsine B and revision of its absolute configuration
- 最新ビタミン学講話 : ビタミン発見100周年を記念して(18)PQQ(ピロロキノリンキノン)
- Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. II : Structure elucidation
- Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae I : Fermentation, isolation and biological properties
- Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942
- Absolute stereochemistry of pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1
- Actinohivin : specific amino acid residues essential for anti-HIV activity
- Xanthoradone C, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2
- Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905
- Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033