Three-Dimensional Structure-Activity Relationship Analysis between Motilin and Motilide Using Conformational Analysis and a Novel Molecular Superposing Method
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概要
- 論文の詳細を見る
Motilide, an erythromycin derivative, has been shown to equal activity to that of motilin as an agonist at the motilin receptor. However, there is little information on the three-dimensional (3D) structure-activity relationship between these two molecules, largely because they have quite different structures. In this study, we applied a rational computational procedure consisting of conformational analysis and a novel superposing method to investigate the 3D structure-activity relationship between motilide and motilin. We propose common 3D structural features between these molecules, which may be important for their similar activity.
- 公益社団法人日本薬学会の論文
- 2000-11-01
著者
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OMURA Satoshi
School of Pharmaceutical Sciences, Kitasato University, Research Center for Biological Function, The
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Sunazuka T
信州大学医学部附属病院 薬剤部
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Sunazuka Toshiaki
Kitasato Univ. Tokyo Jpn
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Sunazuka Toshiaki
School Of Pharmaceutical Sciences Kitasato University:research Center For Biological Function The Ki
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Hirono S
Laboratory Of Physical Chemistry For Drug Design School Of Pharmaceutical Sciences Kitasato Universi
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Hirono Shuichi
School Of Pharmaceutical Sciences Kitasato University
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GOUDA Hiroaki
School of Pharmaceutical Sciences, Kitasato University
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Gouda H
School Of Pharmaceutical Sciences Kitasato University
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Gouda Hiroaki
School Of Pharmaceutical Sciences Kitasato University
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Omura Satoshi
School Of Pharmaceutical Sciences Kitasato University:research Center For Biological Function The Ki
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Omura Satoshi
School Of Pharmaceutical Sciences Kitasato University And Kitasato Institute
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