Noninvasive In-vivo Measurements of Microvessels by Reflection-Type Micro Multipoint Laser Doppler Velocimeter

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概要

• 論文の詳細を見る

• We have developed a micro multipoint laser Doppler velocimeter (μ-MLDV) that enables selective collection of Doppler interference photons. In previous report [H. Ishida et al.: Rev. Sci. Instrum. 82 (2011) 076104], developed the reflection-type μ-MLDV, and showed the results of demonstrations performed on transparent artificial flow channels. In this study, we attempted to perform in-vivo experiments using animals. It can measure absolute velocity and generate tomographs of blood vessels courses. The present system can perform noninvasive in-vivo measurements with a detection limit of about 0.5 mm/s and a spatial resolution in the x--y plane of 125 μm. It is thus able to image venulae. It was used to image venulae in a mouse ear and a subcutaneous blood vessel in a mouse abdomen at a depth of about 1.0 mm below the skin.

• 2012-03-25

著者

• Ishizuka Masaru

  Department Of Mechanical System Engineering Toyama Prefectural University

• Andoh Tsugunobu

  Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

• Andoh Tsugunobu

  Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan

• Ishida Hiroki

  Toyama National College of Technology, Imizu, Toyama 933-0293, Japan

• Akiguchi Shunsuke

  Toyama National College of Technology, Imizu, Toyama 933-0293, Japan

• Hachiga Tadashi

  Toyama National College of Technology, Imizu, Toyama 933-0293, Japan

• Shimizu Tadamichi

  Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan

• Shirakawa Hiroki

  Faculty of Engineering, University of Toyama, Toyama 930-8555, Japan

• Kuraishi Yasushi

  Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan

• Hachiga Tadashi

  Toyama National College of Maritime Technology, 1-2 Ebe-Neriya, Imizu, Toyama 933-0293, Japan

• Ishida Hiroki

  Toyama National College of Maritime Technology, 1-2 Ebe-Neriya, Imizu, Toyama 933-0293, Japan

• Kuraishi Yasushi

  Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

• Ishizuka Masaru

  Department of Mechanics System Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan

• Akiguchi Shunsuke

  Toyama National College of Maritime Technology, 1-2 Ebe-Neriya, Imizu, Toyama 933-0293, Japan

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