Estimation of Scatterer Diameter Using Ultrasonic Backscattering Property for Assessment of Red Blood Cell Aggregation
スポンサーリンク
概要
- 論文の詳細を見る
Red blood cell (RBC) aggregation, a determinant of blood viscosity, plays an important role in blood flow rheology. RBC aggregation is induced by the adhesion of RBCs when the electrostatic repulsion between RBCs weakens owing to increases in protein and saturated fatty acid levels in blood, and excessive RBC aggregation may lead to various circulatory diseases. This study was conducted to establish a noninvasive quantitative method for the assessment of RBC aggregation. The spectrum of nonaggregating RBCs presents Rayleigh behavior, indicating that the power of a scattered wave is proportional to the fourth power of frequency. By dividing the measured power spectrum of echoes from scatterers by that from a silicone plate reflector, the frequency responses of transmitting and receiving transducers are removed from the former spectrum. This normalized power spectrum changes linearly with respect to logarithmic frequency. In non-Rayleigh scattering, on the other hand, the spectral slope decreases because a larger scatterer behaves as a reflector and echoes from a reflector do not show frequency dependence. Therefore, it is possible to assess RBC aggregation using the spectral slope value. In this study, spherical scatterers with diameters of 5, 11, 15, and 30 μm were measured in basic experiments. The spectral slope of the normalized power spectrum of echoes from the lumen of the vein in the dorsum manus of a 24-year-old healthy male was close to that from microspheres with a diameter of 15 μm, and the typical RBC diameter was smaller than this value. The frequency-dependent attenuation of ultrasound during propagation in a biomedical tissue was considered to be one reason for this. Furthermore, during avascularization, the slope gradually decreased owing to the aggregation of RBCs. These results show the possibility of using the proposed method for the noninvasive assessment of RBC aggregation.
- Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
- 2009-07-25
著者
-
Kanai Hiroshi
Graduate School Of Biomedical Engineering Tohoku University
-
Hasegawa Hideyuki
Graduate School Of Biomedical Engineering Tohoku University
-
Saitoh Nobutaka
Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan
関連論文
- Relationship between upper limb peripheral artery stiffness using the radial artery and atherosclerotic parameters
- Tissue structure of arterial wall revealed with elasticity imaging
- Cross-Sectional Elasticity Imaging of Arterial Wall by Comparing Measured Change in Thickness with Model Waveform
- Measurement and analysis of vibration in the myocardium telescopic motion for novel echo-graphic diagnosis
- Tissue Characterization of Atherosclerotic Plaque by Ultrasonic Measurement of Regional Elasticity
- Ultrasonic Measurement of Regional Elasticity of Arterial Wall for Evaluation of Vulnerability of Atherosclerotic Plaque
- Two-Dimensional Tracking of Heart Wall for Detailed Analysis of Heart Function at High Temporal and Spatial Resolutions
- Ultrasonic Imaging of Propagation of Contraction and Relaxation in the Heart Walls at High Temporal Resolution
- Reduction of Influence of Decrease in Signal-to-Noise Ratio in Measurement of Change in Thickness of Arterial Wall Due to Heartbeat
- Accuracy Evaluation in the Measurement of a Small Change in the Thickness of Arterial Walls and the Measurement of Elasticity of the Human Carotid Artery
- Automated Identification of the Heart Wall Throughout the Entire Cardiac Cycle Using Optimal Cardiac Phase for Extracted Features
- Noninvasive Measurement of Transient Change in Viscoelasticity Due to Flow-Mediated Dilation Using Automated Detection of Arterial Wall Boundaries
- Multi Element Diverging Beam from a Linear Array Transducer for Transverse Cross Sectional Imaging of Carotid Artery: Simulations and Phantom Vessel Validation
- Measurement of Angular Dependence of Ultrasonic Scattering from Wire Phantom Mimicking Myocardial Fiber
- In Vivo Measurement of Small Velocity Signals and Change in Thickness of the Heart Walls
- Ultrasonic Measurement of Transient Change in Stress–Strain Property of Radial Arterial Wall Caused by Endothelium-Dependent Vasodilation
- Modified Phased Tracking Method for Measurement of Change in Thickness of Arterial Wall
- High-frame-rate echocardiography using diverging transmit beams and parallel receive beamforming
- Improvement in Accuracy of Ultrasonic Measurement of Transient Change in Viscoelasticity of Radial Arterial Wall Due to Flow-Mediated Dilation by Adaptive Low-Pass Filtering (Special Issue : Ultrasonic Electronics)
- Evaluation of Rate of Change in Thickness of Heart Wall by Measuring Time Variation of Ultrasonic Integrated Backscatter during a Cardiac Cycle (Special Issue : Ultrasonic Electronics)
- Frequency Analysis of Strain of Cylindrical Shell for Assessment of Viscosity
- Construction of Reference Data for Tissue Characterization of Arterial Wall Based on Elasticity Images
- Optimization of Correlation Kernel Size for Accurate Estimation of Myocardial Contraction and Relaxation
- Tissue Classification of Arterial Wall Based on Elasticity Image
- Measurement of displacement and strain in biological tissue generated by ultrasonic dual acoustic radiation force
- Basic Study on Detection of Outer Boundary of Arterial Wall Using Its Longitudinal Motion
- Change in Elasticity Caused by Flow-Mediated Dilation Measured Only for Intima–Media Region of Brachial Artery
- Measurement of Angular Dependence of Ultrasonic Echo for Estimation of Surface Roughness
- Cross-Sectional Elastic Imaging of Arterial Wall Using Intravascular Ultrasonography
- Modeling of Ultrasonic Echo from Posterior Arterial Wall for Accurate in-vivo Detection of Intima-Media Complex Boundaries
- Cross-Sectional Elasticity Imaging of Carotid Arterial Wall in Short-Axis Plane by Transcutaneous Ultrasound
- Generation of Strain Inside Objects Using Dual Acoustic Radiation Force
- Threshold Setting for Likelihood Function for Elasticity-Based Tissue Classification of Arterial Walls by Evaluating Variance in Measurement of Radial Strain
- Measurement of Elastic Moduli of the Arterial Wall at Multiple Frequencies by Remote Actuation for Assessment of Viscoelasticity
- Measurement of Change in Wall Thickness of Cylindrical Shell Due to Cyclic Remote Actuation for Assessment of Viscoelasticity of Arterial Wall
- Estimation of Scatterer Diameter Using Ultrasonic Backscattering Property for Assessment of Red Blood Cell Aggregation
- Designing Beam Steering for Accurate Measurement of Intima-Media Thickness at Carotid Sinus
- Detection of Arterial Wall Boundaries Using an Echo Model Composed of Multiple Ultrasonic Pulses (Special Issue : Ultrasonic Electronics) -- (Biomedical ultrasound)
- Accurate Ultrasonic Measurement of Surface Profile Using Phase Shift of Echo and Inverse Filtering
- Improvement of Automated Identification of the Heart Wall in Echocardiography by Suppressing Clutter Component
- Investigation of Frequency Characteristics in Cutting of Soft Tissue Using Prototype Ultrasonic Knives
- Automated Detection of Intima-Media Complex Boundaries in Longitudinal Section of Carotid Artery by Fitting Echo Model Composed of Multiple Ultrasonic Pulses to Measured Signal
- Ultrasonic Measurement of Minute Displacement of Object Cyclically Actuated by Acoustic Radiation Force
- Increasing Bandwidth of Ultrasound Radio Frequency Echoes Using Wiener Filter for Improvement of Accuracy in Measurement of Intima--Media Thickness
- Flow-Mediated Change in Viscoelastic Property of Radial Arterial Wall Measured by 22 MHz Ultrasound
- Ultrasonic Measurement of Change in Elasticity due to Endothelium Dependent Relaxation Response by Accurate Detection of Artery-Wall Boundary
- Modeling of Ultrasonic Echo from Posterior Arterial Wall for Accurate in-vivo Detection of Intima-Media Complex Boundaries