Human Genome Encodes Many Proteins with Charge Periodicity of 28 Residues
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概要
- 論文の詳細を見る
The human genome includes more than 36,000 open reading frames that are translated to amino acid sequences of proteins. When the charge distribution in amino acid sequences from the total human genome was analyzed by the autocorrelation function, a surprisingly sharp periodicity of 28 residues was observed. Every protein with the charge periodicity of 28 residues (PCP28) could be discriminated by a simple algorithm, and the number of PCP28 amounted to about 3% of the total open reading frames of the human genome. The net charge of most PCP28 was highly positive. The possible structural and functional features of this type of protein were discussed in terms of the electric repulsion within molecules.
- 2007-09-15
著者
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Ke Runcong
Department Of Applied Physics Graduate School Of Engineering Nagoya University
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Sonoyama Masashi
Department Of Applied Physics Graduate School Of Engineering Nagoya University
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Sakiyama Noriyuki
Department Of Applied Physics Nagoya Universitycomputattonal Biology Research Center National Instit
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Sawada Ryusuke
Department Of Applied Physics Graduate School Of Engineering Nagoya University
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Mitaku Shigeki
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
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Sonoyama Masashi
Department of Applied Physics, Graduate School of Engineering, Nagoya University, Furocho, Chikusa-ku, Nagoya 464-8603, Japan
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Sakiyama Noriyuki
Department of Applied Physics, Graduate School of Engineering, Nagoya University, Furocho, Chikusa-ku, Nagoya 464-8603, Japan
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Mitaku Shigeki
Department of Applied Physics, Graduate School of Engineering, Nagoya University, Furocho, Chikusa-ku, Nagoya 464-8603, Japan
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