散剤秤量時の調剤環境が及ぼす調剤者曝露への影響:-散剤抗がん薬調剤での意義-

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There has been no detailed evaluation of preventive measures against exposure to oral powdered preparations of antineoplastic drugs during dispensation.In this study,we examined the effectiveness of using a dust collector in the drug dispensing environment with respect to drug dispersal as well as other contamination-related factors.Preparations of lactose powder,fine lactose granules and busulfan powder containing fluorescein sodium at 0.05 w/w% were made,and the pressure gradient of the dust collector on the powder dispensation table was set at 150,60,20,and 0 Pa.After weighing the preparations,under UV irradiation,fluorescence spots were observed on the dispensation table and masks for all pressure gradients,indicating that exposure is unavoidable.At 150 Pa,there were significantly more fluorescence spots of lactose powder on the dispensation table at 150 Pa than at 20 or 60 Pa.Also,for lactose granules,there were high concentrations of fluorescence spots in particular areas for lactose,indicating that this was an undesirable pressure gradient under which exposure was high.Fluorescence spots were also detected on powder bottles and gloves,indicating the possibility of secondary contamination and importance of cleaning immediately after weighing.The order of dispersion amounts was : lactose granules>busulfan>lactose powder,so lactose granules were considered undesirable for the dosage form of antineoplastic drugs.Regarding dispersal patterns,there were large numbers of fluorescence spots in areas closer to the dispenser at 0 Pa,and also concentrations of them in distant areas,so dispenser exposure was considered to be higher at 0 Pa.These results suggest that dispenser exposure to powdered antineoplastic drugs due to dispersion can be reduced by running the dust collector on the dispensation table at a low to medium power level.
日本医療薬学会の論文

散剤秤量時の調剤環境が及ぼす調剤者曝露への影響:-散剤抗がん薬調剤での意義-

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