副鼻腔由来培養骨芽細胞の石灰化制御機構:Vitamin D3, K2, warfarinによる刺激効果

概要

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Many reports demonstrated that some histological changes occurred in paranasal sinus bones in acute and/or chronic sinusitis, but only a few authors discussed the metabolic mechanisms of these changes. Recently, it has been reported in other fields, such as orthopedics, that stimulating osteoblasts with both Vitamin D3 and K2 improved bone metabolisms. In this study, we investigate metabolic mechanisms of paranasal sinus bones in chronic sinusitis by stimulating osteoblasts with Vitamin D3, Vitamin K2 and warfarin, which is an antagonist of Vitamin K2. Stimulation with both Vitamin D3 and K2 increased mineralization ability, osteocalcin concentrations and alkaline phosphatase activities, and the addition of warfarin to Vitamin D3 and K2 decreased these effects in cultured osteoblasts. Our study demonstrates that these agents may regulate the metabolism of human paranasal sinus bones, and that using these agents in therapies for sinusitis might lead to further improve of treatment effects.
耳鼻咽喉科臨床学会の論文