上顎悪性黒色腫に対する動注療法の試み

概要

論文の詳細を見る
We investigated the radius and width of tumor invasion as well as the sites of metastasis in cases with malignant melanoma, by scintigraphy using N-isopropyl-P-(123I) iodoamphetamine (IMP) (referred to as 123I-IMP). Simultaneous administration of L-Dopa with intra-arterial drug infusion therapy, significantly reduced the accumulation of radioactivity from 123I-IMP in the tumor lesion. This indicated that L-Dopa might have an affinity for melanoma cells, as it replaced 123I-IMP in the tumor lesion. Consequently, L-Dopa might be effective in the treatment of malignant melanoma. Furthermore, wereported the results of the combined administration of L-Dopa and 5-(3,3'-dimethyl-I-triazeno) -imidazole-4-carboxamide for the treatment of malignant melanoma.
耳鼻咽喉科臨床学会の論文