興奮伝達時間の左心室壁運動に与える影響―リング形状左心室モデルによるシミュレーション研究―:—リング形状左心室モデルによるシミュレーション研究—

概要

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The heart is an organ with highly complex structure and its pump function is affected by various factors. Many reports showed the strong relation between the excitation-propagation phenomenon in the heart and its pump function. But the experimental studies often failed to provide the mechanistic insights due to the complex cross-talks built in these processes. In this study, we focus on the relation between the activation time and the contraction of the tissue. The contraction simulation coupled with the excitation propagation simulation was performed using the finite element model of the ventricular ring. We performed the simulation with 7 types of stimulation with various pacing sites in the tissue, and compared the pump functions by the area ejection fraction. The results showed that when the activation time became long, the area ejection fraction became nonlinearly small. The results of this study showed the excitation propagation is one of the important parameter of the left ventricular wall motion.
一般社団法人日本生体医工学会の論文