The Effect of Growth Hormone on the Developing Brain
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概要
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This article attempts to summarize the available literature concerned with the morphological and biochemicaleffects of growth hormone (GH) on brain development.<BR>Review of experimental works is as follows. In early hypophysectomized rats, the mortality rate was very high during the immediate postoperative periods. The death may be attributed to the brain damage due to the increased intracranial pressure and the herniation of the brain stem into the foramen magnum caused by the postoperative deformity of the skull. There were marked differences in body weight, body length, weights of endocrine organs and osteogenesis betweenearly hypophysectomized and normal rats. Hypophysectomy also resulted in the vertical increase in the volume of diencephalon, the decrease of acetylcholinesterase activities in the somatosensory and ventral cortex, the decrease of cholinesterase activity in the hypothalamus, fall in the synthesis of RNA and protein of the brain, and lack of the large polysomes.<BR>GH, when given to frog larvae, increased the cell number and the weight of brain. Similar findings were reported on the effect of maternal treatment of bovine GH on neonatal rat. These results indicated that this hormone enhanced mitosis and thereby increased tissue mass in the developing brain.<BR>The review of clinical study reveals that the patients with pituitary dwarfism with high serum concentration of an immunoreactive but biologically inactive human GH showed low IQ's by Wechsler Intelligence test and below age norms by Bender Gestalt test. This suggested a recognizable pattern of organic impairment of central nervous system in the deficiency state of human GH.
- 一般社団法人 日本小児神経学会の論文
一般社団法人 日本小児神経学会 | 論文
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