Relation among Serum Diphenylhydantoin Concentrations, Clinical Response and Toxic Signs in Epileptic Children
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概要
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1. Relationship between serum concentration and the clinical effect was investigated on the epileptic children of grand mal type without mental retardation who had the convulsive seizures within one year prior to starting the present study.<BR>In 13 cases, the seizure were well controlled after the initiation of diphenyl hydantoin administration and/or an increase in the dose of the drug, and in all these cases serum levels of diphenylhydantoin were above 9.0, μg/ml.<BR>In 19 cases which showed no clinical improvement, serum diphenylhydantoin levels below 8.6μg/ml were found in 15 cases, and the remaining 4 cases showed the drug concentration above 14.2μg/ml and were treated with other anticonvulsants with successful results.<BR>2. Out of 177 cases of epilepsy with diphenylhydantoin administration, toxic signs due to the drug administration were found in 14 cases, in all of which serum diphenylhydantoin levels were found above 22.0μg/ml.
- 一般社団法人 日本小児神経学会の論文
一般社団法人 日本小児神経学会 | 論文
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