Effect of Diphenylhydantoin Administration on Folate Metabolism

概要

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When rats were fed on folate deficient diet and given diphenylhydantoin (DPH), it was found that the utilization of single carbon from formimino glutamic acid and formate via folate metabolic pathway proceeded in liver more efficiently than that in folate deficient rats without DPH administration.<BR>A suppressive action of exogenous supply with deoxyuridine upon incorporation of <SUP>3</SUP>H-thymidine into DNA in bone marrow cells was examined, and the result revealed that there was no differnce in the 3H-thymidine incorporation into DNA in bone marrow cells of folate deficient rats with or without DPH administration. This finding suggested that there was no possibility that an increased amount of methylene tetrahydrofolate might be available for DNA synthetic pathway in bone marrow cells of folate deficient rats with DPH administration.
一般社団法人日本小児神経学会の論文