Clinical and Clinicopathological Studies on Severe Perinatal Brain Damaged Children

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16 cases of severe brain damaged children suffered from obstetrical abnormalities were analysed clinicopathologically.<BR>Neurological findings revealed severe mental retardation, epilepsy and many types of motor dysfu nction, i. e. spastic, rigid or rigid-spastic tetraparesis with or without athetosis.<BR>EEG tended to reveal seizure activities with central and occipital foci.<BR>PEG was performed in 8 cases, and 4 of them revealed localized ventricular dilatation, which sug gested the localized brain atrophy in bilateral central and occipital area. And in another 4 cases, PEG revealed marked diffuse ventricular dilatation.<BR>In 3 autopsy cases, brain surface showed marked cortical sclerosis around bilateral precentral gyrus and occipital area. These findings may be correlated with the localized ventricular dilatation revealed in PEG, and are thought to be the sequelae of the cortical damage due to mculding at coronal and lambdoid suture in birth canal or by mechanical compression at delivery.
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