A Case Report of SSPE:With Immunological Consideration

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A six-year-nine-month old boy was admitted to our hospital with complaints of personality changeand involuntary movements. He had sudden grand mal-like seizure 7 weeks prior to this admission, and since then graduallydeveloped personality changes. His initial EEG record had shown no specific abnormality. The diagnosis of SSPE was made by his clinical course, specific EEG changes since admission, colloidal gold curve of CSF, and markedly elevated serum anti-measles antibody titer. He had suffered from measles uneventfully at the age of three.According to Burnet (1968), SSPE is a condition in which the thymus-dependent system has developedspecific tolerance (non-responsiveness) to measles antigen while the antibody system remainsspecifically active. As to our case, delayed hypersensitivity to candida skin test and blastogenesis of lymphocytes to PHA were normal, and blastogenesis to measles virus showed also normal reaction compared with thenormal control. From these data, in our case, cellular immunity was considered completely intact, and no specifictolerance to measles virus was proved. He died after eight months' clinical course and the pathological examination was not performed.
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