Proinflammatory Cytokine Levels in Cerebrospinal Fluid from Children with Acute Encephalitis.

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We investigated interleukin-1β(IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), and soluble TNF receptor 1 (sTNF-R 1) during the acute stage in the cerebrospinal fluid (CSF) from children with acute encephalitis by means of a sandwich enzyme immunoassay. We divided the 24 children with acute encephalitis into two groups: those who survived without neurological sequelae (Group 1, n= 15), and those who died or were left with sequelae (Group 2, n=9). The IL-1β, IL-6, TNF-α and sTNF-R 1 levels in CSF in the two groups were significantly higher than those in control subjects (n=23). The CSF sTNF-R 1 levels in Group 2 were significantly higher than those in Group 1. Our findings suggest that the IL-1β, IL-6 and TNF-α in CSF are related to the pathogenesis of acute encephalitis, and that the CSF level of sTNF-R1 during the acute stage of encephalitis is an important index for predicting the neurological outcome.
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