Serial MR Imaging of Possible Pelizaeus-Merzbacher Disease.

スポンサーリンク

概要

• 論文の詳細を見る

• We performed serial magnetic resonance imaging (MRI) toward 4 male children with possible Pelizaeus- Merzbacher disease (PMD). They were clinically suspected as PMD on the basis of typical neurological, electrophysiological and MRI examinations. MRI revealed that myelinated fibers were localized in brainstem, cerebellum, internal capsule, optic radiation and proximal corona radiata in case 1, while myelinated fibers were almost absent in case 2-4. On repeated MRI investigation, we found no further extension of myelination in case 1 and the absence of myelination in case 2-4. This study demonstrated that myelination in the brain is arrested immediately after birth in case 1, while no myelination developed before birth in case 2-4. It was speculated that MRI in case 1 and case 2-4 might correspond to neuropathologic findings of classical and connatal form as reported in the literature.

• 一般社団法人 日本小児神経学会の論文

一般社団法人 日本小児神経学会 | 論文

• Levetiracetamが著効したSTXBP1遺伝子変異による大田原症候群の1例
• Cyclophosphamideが著効した抗NMDA受容体抗体脳炎の8歳男児例
• 重症心身障害医療からみた小児脳死に関する私見
• 幼児期発症の難治な多発性硬化症に対しcyclophosphamideパルス療法が有効であった1例
• Duchenne型筋ジストロフィー児への病気の説明に関する調査

もっと見る

スポンサーリンク