Experimental study on pathogenesis of neonatal hypoxic-ischemic encephalopathy. I. Histopathological study.:I. Histopathological Study

スポンサーリンク

概要

• 論文の詳細を見る

• This experiment was undertaken to study the effect of hypoxic and/or ischemic condition on developing brain and also to investigate the pathogenesis of hypoxic-ischemic encephalopathy.<BR>A unilateral common carotid artery of 7-day-old Sprague-Dawlay rats was ligated and cut under ether inhalation. Three hours after the operation, these rats were exposed to hypoxia (8% oxygen and 92% nitrogen mixture) for two hours. Three days after manipulation, neuronal necrosis on the ligated hemisphere were recognized in 50%in the cortex, 66.7%in the hippocampus, 66.7% in the corpus striatum and 33.3% in the thalamus. Various sizes and degrees of necrotic regions were found in the cerebral cotex. In some cases, cuffs of radially arranged viable neurons alternating with stripes of full-depth necrosis of the cortex were noticed. In the hippocampus, neuronal necrosis was found segmentally at the pyramidal cell layer. In the corpus striatum and the thalamus, the damage consisted of small focal or multifocal neuronal necrosis. After four and eight weeks of the manipulation, a large porencephalic cavity in the cerebral cortex of the ligated side was noticed as the severest manifestation in 16% of the cases. In some cases, multiple lobulation similar to polymicrogyrus was noticed. Various sizes of gliosis were also numerous in the cerebral cortex, hippocampus, corpus striatum and thalamus of the ligated side hemisphere. Calcified lesions were also occasional in the basal ganglia.

• 一般社団法人 日本小児神経学会の論文

一般社団法人 日本小児神経学会 | 論文

• Levetiracetamが著効したSTXBP1遺伝子変異による大田原症候群の1例
• Cyclophosphamideが著効した抗NMDA受容体抗体脳炎の8歳男児例
• 重症心身障害医療からみた小児脳死に関する私見
• 幼児期発症の難治な多発性硬化症に対しcyclophosphamideパルス療法が有効であった1例
• Duchenne型筋ジストロフィー児への病気の説明に関する調査

もっと見る

スポンサーリンク